Pomalidomide-PEG5-CO2H

 CAS No.: 2139348-63-1  Cat No.: BP-100022  Purity: ≥98% 4.5  

Pomalidomide-PEG5-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal carboxylic acid for reactivity with an amine on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Pomalidomide-PEG5-CO2H

Structure of 2139348-63-1

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E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C26H35N3O11
Molecular Weight
565.57

* For research and manufacturing use only. Not for human or clinical use.

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25 mg $259 In stock

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Purity
≥98%
ShelfLife
2 years
Storage
Store at -20°C
IUPACName
3-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Synonyms
1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
InChI Key
PMCQLKMOQUEEDR-UHFFFAOYSA-N
InChI
InChI=1S/C26H35N3O11/c30-21-5-4-20(24(33)28-21)29-25(34)18-2-1-3-19(23(18)26(29)35)27-7-9-37-11-13-39-15-17-40-16-14-38-12-10-36-8-6-22(31)32/h1-3,20,27H,4-17H2,(H,31,32)(H,28,30,33)
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCOCCC(=O)O

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Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
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Historical Records: t-Boc-N-amido-PEG2-amine | Thalidomide-NH-PEG1-NH2 hydrochloride | ABBV-744 | Pomalidomide-PEG2-NH2 dihydrochloride | (S,R,S)-AHPC-PEG2-NH2 hydrochloride | cIAP1 Ligand-Linker Conjugates 6 hydrochloride | (S,R,S)-AHPC-PEG1-azide | PROTAC K-Ras Degrader-1 | Pomalidomide-PEG1-azide | VH 032-linker 6 | Pomalidomide-PEG5-CO2H

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