Propargyl-PEG25-acid
Cat No.: BP-502052
4.5 
Propargyl-PEG25-acid is a PEG-based bifunctional linker featuring a terminal propargyl (alkyne) group and a carboxylic acid at the opposite end, connected through a long, flexible polyethylene glycol chain that provides aqueous solubility and conformational spacing. In PROTAC and related targeted protein degradation designs, the propargyl handle enables chemoselective conjugation via copper-catalyzed or strain-promoted azide–alkyne cycloaddition, allowing attachment to azide-functional warheads (e.g., ligand-bearing E3 ligase recruiters) or to other PROTAC modules without significantly perturbing binding motifs. The carboxylic acid can be used for amide coupling or other derivatization to tune linker length, polarity, and the relative orientation of the recruited proteins, thereby influencing ternary complex formation and degradation efficiency. This linker is valuable for systematic structure–activity studies where researchers need stable, modular assembly of multicomponent degradation constructs under aqueous conditions.
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* For research and manufacturing use only. Not for human or clinical use.
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Propargyl-PEG25-acid is a PEG-based PROTAC linker designed to provide a flexible, hydrophilic spacer between a ligand and an E3-recognition element. Its terminal propargyl group enables efficient conjugation via alkyne-compatible coupling strategies, while the terminal carboxylic acid supports controlled attachment and downstream functionalization. The PEG architecture can help modulate solubility, reduce non-specific interactions, and improve the effective reach of the recruited proteins. Detailed structural and reactivity considerations are provided below.
Structure: This linker contains a long polyethylene glycol chain providing hydrophilicity and conformational flexibility, flanked by a propargyl (terminal alkyne) functionality and a terminal carboxylic acid. It features ether linkages along the PEG backbone, a carbon-carbon triple bond at the propargyl terminus, and a carboxylate-bearing group for ionic interactions.
Reactivity: The terminal alkyne is suitable for copper-catalyzed azide–alkyne cycloaddition or related alkyne click chemistries, enabling modular assembly of PROTACs from complementary azide-bearing fragments. The carboxylic acid can be activated for amide-bond formation using standard coupling reagents under mild base conditions. Typical solvents include polar aprotic media for activation steps, followed by aqueous-compatible conditions for final conjugation and purification.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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