Propargyl-PEG3-phosphonic acid
CAS No.: 1714139-62-4
Cat No.: BP-501172
Purity: 98%
4.5 
Propargyl-PEG3-phosphonic acid is a PEG-based linker bearing a terminal propargyl group and a phosphonic acid functionality, providing a chemically versatile scaffold for PROTAC and targeted protein degradation workflows. Structurally, it comprises a short, three–ethylene glycol unit chain that confers aqueous solubility and spatial flexibility, while the propargyl handle enables copper-catalyzed azide–alkyne cycloaddition or related click-type conjugation strategies to connect the linker to one PROTAC module. The phosphonic acid group offers a strong, anionic interaction motif that can be used to tune local charge distribution and, in appropriate designs, to support conjugation or coordination-based attachment to complementary moieties. In PROTAC construction, this combination of a reactive alkynyl terminus and a phosphonic acid anchor helps researchers rationally position binding elements to promote effective ternary complex formation. As a linker reagent, it is valuable for generating degraders with improved solubility and controllable linker geometry, facilitating systematic structure–activity relationship studies in targeted degradation research.
Structure of 1714139-62-4
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Propargyl-PEG3-phosphonic acid is a versatile PROTAC linker building block designed to connect targeting ligands through a PEG-based spacer while incorporating a phosphonic acid handle for robust conjugation strategies. Its flexible, hydrophilic architecture can help tune linker solvation and presentation to improve ternary complex formation. The propargyl functionality enables reliable click-type coupling, and the phosphonic acid provides an additional orthogonal reactive motif. Detailed structural and synthetic considerations are provided below.
Structure: This linker combines a terminal propargyl group with a short polyethylene glycol chain and a phosphonic acid moiety. It contains carbon–carbon and carbon–oxygen bonds within the PEG segment, along as a carbon–carbon triple bond suitable for bioorthogonal coupling, and a phosphorus–oxygen framework that confers strong acidity and metal-binding character.
Reactivity: The propargyl group is well suited for copper-catalyzed azide–alkyne cycloaddition or related alkyne-based conjugation approaches, typically requiring an appropriate azide partner, a compatible copper catalyst system, and oxygen-tolerant conditions to preserve sensitive ligands. The phosphonic acid can participate in coupling workflows that rely on activation of the P–OH group or coordination-assisted assembly, often using polar, buffering-compatible solvents to maintain solubility and functional-group stability during PROTAC construction.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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