Propargyl-PEG6-thiol
CAS No.: 1422540-91-7
Cat No.: BP-501645
Purity: >95%
4.5 
Propargyl-PEG6-thiol is a bifunctional polyethylene glycol linker featuring a terminal alkyne (propargyl) and a terminal thiol, connected through an approximately six-unit PEG chain that provides strong aqueous solubility and conformational flexibility. The propargyl group enables bioorthogonal conjugation via copper-catalyzed azide–alkyne cycloaddition (CuAAC), allowing attachment to azide-bearing targeting ligands, handles for surface immobilization, or reporter tags. The thiol can participate in thioether formation through alkylation or Michael-type chemistry, or be used for controlled disulfide exchange strategies to introduce reversible connectivity to cysteine-containing biomolecules. In PROTAC and targeted degradation workflows, this linker serves as a modular spacer that positions the E3-ligase ligand and the target-binding moiety to improve productive ternary complex formation while reducing steric interference and aggregation. Its PEG-based distance control and orthogonal functional groups make it valuable for systematic linker optimization and for constructing degraders with improved handling and solubility in biochemical assays.
Structure of 1422540-91-7
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Propargyl-PEG6-thiol is a bifunctional PROTAC linker designed to connect a thiol-bearing handle to an alkyne-bearing coupling site, enabling modular assembly of targeted protein degradation constructs. Its polyethylene glycol spacer provides conformational flexibility and improved solubility, while the terminal thiol supports chemoselective conjugation strategies. The molecule is commonly used as a practical intermediate for building PROTACs, where the linker’s spacing and reactivity directly influence effective ternary complex formation. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains a terminal alkyne introduced via a propargyl group and a terminal thiol, separated by a PEG-based polyether chain. It features ether linkages in the PEG segment, a carbon–carbon triple bond in the alkyne, and a thiol functional group capable of forming thioethers or thioester derivatives under appropriate conditions.
Reactivity: PROTAC assembly using this linker typically relies on chemoselective coupling of the thiol and alkyne functionalities. The thiol can be converted to activated derivatives or used in thiol–functional group conjugations, while the alkyne is suitable for click-type bond formation (commonly copper-catalyzed azide–alkyne cycloaddition) when paired with an azide-bearing partner. Mild, oxygen-aware conditions and compatible solvents are generally selected to preserve thiol integrity and maintain linker solubility during stepwise synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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