Sulfo-LC-SDA
CAS No.: 1909307-62-5
Cat No.: BP-502164
Purity: ≥ 90%
4.5 
Sulfo-LC-SDA is a water-soluble, long-chain heterobifunctional photo-crosslinker containing an amine-reactive sulfo-NHS ester and a diazirine group. Structurally, the sulfonated NHS ester enables coupling to primary amines, while the long-chain spacer positions a 3-methyldiazirine group for UV-activated covalent capture of nearby biomolecular partners. In PROTAC and related targeted degradation workflows, such linkers are used to connect a ligand-bearing moiety to a second functional component while maintaining sufficient spatial separation to preserve binding and enable productive ternary-complex formation. The sulfonate improves aqueous handling and reduces nonspecific aggregation, which can be advantageous during labeling, purification, and subsequent degradation assays. Overall, Sulfo-LC-SDA provides a practical platform for constructing well-defined conjugates and optimizing linker length and polarity to support robust targeted protein degradation research.
Structure of 1909307-62-5
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Sulfo-LC-SDA is a specialized PROTAC linker designed to connect a target-binding ligand to an E3-recruiting moiety while supporting efficient formation of a productive ternary complex. Its sulfated, hydrophilic linker architecture is intended to improve aqueous compatibility and maintain favorable linker solvation and presentation. This product is commonly used in targeted protein degradation workflows, where the subsequent sections below describe its structural features and practical considerations for linker-enabled PROTAC synthesis.
Structure: Sulfo-LC-SDA incorporates a sulfonate-containing, hydrophilic linker segment that promotes strong polarity and water solubility. The scaffold contains stable covalent bonds suitable for bioconjugation chemistry, with functional handles positioned to enable conjugation to PROTAC warheads and recruiting ligands via established linker-forming strategies.
Reactivity: Sulfo-LC-SDA is typically employed under bioconjugation-compatible conditions that preserve sulfonate integrity and maintain functional-group reactivity. Linker coupling is generally performed using standard amide or related bond-forming chemistries, guided by the complementary reactive groups on the partner ligands. Common approaches use activating reagents and mild bases in aqueous or mixed aqueous/organic solvents, with temperature and pH optimized to minimize side reactions and maximize coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
