TCO-PEG12-acid
Cat No.: BP-501987
Purity: 95%
4.5 
TCO-PEG12-acid is a heterobifunctional, polymeric PROTAC linker featuring a trans-cyclooctene (TCO) reactive handle conjugated to a polyethylene glycol (PEG) chain of extended length terminating in a carboxylic acid. The PEG spacer provides conformational flexibility and hydrophilicity, helping to reduce steric constraints between the two binding elements of a targeted degrader. In PROTAC workflows, the TCO moiety serves as a bioorthogonal “click” partner for tetrazine-containing partners, enabling rapid conjugation or late-stage assembly of PROTACs and related degraders under mild conditions. The terminal acid supports standard coupling chemistries to attach the linker to ligands or to incorporate it into larger constructs. This product is valuable for researchers seeking modular, efficient assembly of TCO–tetrazine degraders, improved solubility, and tunable linker length to optimize ternary complex formation and degradation performance in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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Popular Publications Citing BOC Sciences Products
TCO-PEG12-acid is a polyethylene glycol (PEG)-based PROTAC linker designed to connect targeting ligands through a reactive trans-cyclooctene (TCO) handle and a terminal carboxylic acid for controlled conjugation. Its flexible, hydrophilic PEG segment supports productive ternary complex formation and improves solubility and handling in linker-ligation workflows. The molecule is widely applicable in PROTAC technology where orthogonal chemistries enable modular assembly of degraders; the following points describe its structure and reactivity in detail below.
Structure: The linker comprises a PEG chain terminating in a carboxylic acid, providing a polar, conformationally flexible scaffold. The TCO moiety contains a strained cyclooctene alkene suitable for bioorthogonal reactions. Overall, it features ether linkages along the PEG backbone and a functional acid for amide or ester formation.
Reactivity: The terminal carboxylic acid enables coupling to amine-bearing ligands via standard carboxyl-activation chemistries, such as carbodiimide-mediated amide bond formation, typically in polar organic/aqueous mixtures. The TCO group undergoes rapid, catalyst-free inverse-electron-demand cycloaddition with tetrazines under mild conditions, with the mechanism driven by strain release and cycloaddition. For PROTAC assembly, choose buffers that maintain ligand stability and minimize premature TCO consumption.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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