Tetrazine-Ph-NHCO-PEG3-alcohol
Cat No.: BP-502081
4.5 
Tetrazine-Ph-NHCO-PEG3-alcohol is a heterobifunctional PROTAC linker building block featuring a tetrazine moiety conjugated through a phenyl spacer to a carbamoyl-linked short polyethylene glycol chain terminating in a primary alcohol. Structurally, the PEG3 segment provides aqueous solubility and conformational flexibility, while the tetrazine group enables rapid, bioorthogonal inverse-electron-demand Diels–Alder reactivity with trans-cyclooctene or related strained-alkene partners, allowing modular assembly of PROTACs under mild conditions. In targeted protein degradation workflows, this linker can be used to connect a ligand-bearing tetrazine handle to a complementary trans-cyclooctene-functionalized component, thereby positioning the two recognition elements to promote effective ternary complex formation with the E3 ligase and the target protein. Its value lies in facilitating efficient late-stage conjugation, reducing synthetic steps, and improving handle compatibility for constructing degraders with tunable linker properties for mechanistic and optimization studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Tetrazine-Ph-NHCO-PEG3-alcohol is a bifunctional PROTAC linker designed to integrate a tetrazine handle with a polyethylene glycol spacer and a terminal alcohol for flexible conjugation. Its chemical architecture supports modular assembly of targeted protein degraders by enabling efficient coupling to ligands while providing solubility and controlled linker length for productive ternary complex formation. The following points describe the structure and the practical reactivity considerations for PROTAC construction in detail below.
Structure: The linker contains a tetrazine moiety conjugated to a phenyl group, an amide (NHCO) linkage, and a PEG-based ether chain terminating in a primary alcohol. It features aromatic and heteroaromatic systems, hydrogen-bonding sites from the amide, and multiple ether oxygens that enhance hydrophilicity and conformational flexibility.
Reactivity: The tetrazine functionality is suitable for bioorthogonal inverse-electron-demand Diels–Alder chemistry with strained dienes (e.g., trans-cyclooctene derivatives), enabling rapid conjugation under mild conditions. The terminal alcohol can be converted to activated intermediates (such as carbonate or ester derivatives) for subsequent coupling to amine- or carboxyl-bearing ligands. Amide stability supports robust linker integrity during typical PROTAC synthesis and purification workflows.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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