Tetrazine-Ph-NHCO-PEG4-alkyne
Cat No.: BP-501930
4.5 
Tetrazine-Ph-NHCO-PEG4-alkyne is a bifunctional PROTAC linker built on a tetrazine–phenyl amide core conjugated to a short polyethylene glycol spacer terminating in an alkyne. The tetrazine moiety is designed for rapid inverse-electron-demand Diels–Alder bioorthogonal reactions with strained dienophiles, enabling efficient, catalyst-free conjugation to complementary partners during PROTAC assembly or labeling. The PEG4 segment provides aqueous solubility and conformational flexibility, helping to reduce steric interference between the targeting ligand and the E3-recruiting or payload module. The terminal alkyne serves as a reactive handle for orthogonal click-type functionalization or for attachment to alkyne-reactive components, facilitating modular synthesis workflows. In targeted protein degradation research, this linker supports controlled spatial presentation of functional groups, improving the likelihood of productive ternary complex formation while allowing streamlined characterization and site-specific derivatization of PROTAC constructs.
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* For research and manufacturing use only. Not for human or clinical use.
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This Tetrazine-Ph-NHCO-PEG4-alkyne linker is engineered for modular PROTAC assembly, combining a bioorthogonal tetrazine handle with a PEG-based solubilizing segment and an alkyne for orthogonal conjugation strategies. Its flexible ether-rich architecture supports productive ternary complex formation, while the reactive tetrazine enables rapid, selective capture of compatible partners under mild conditions. The subsequent points describe its structure and practical reactivity considerations for constructing targeted protein degradation reagents in research workflows.
Structure: The linker contains an aryl (phenyl) core flanked by an amide linkage and an ether-rich PEG segment, terminating in an alkyne. It features heteroatoms that enhance polarity and solubility, with conjugated aromatic and amide carbonyl functionalities that support stable coupling to PROTAC scaffolds.
Reactivity: Tetrazine-based reactivity is typically exploited via strain-promoted inverse-electron-demand Diels–Alder chemistry with suitable unsaturated partners, enabling fast, selective ligation under aqueous-compatible conditions. The alkyne functionality can be used for orthogonal click-style conjugation depending on the chosen coupling chemistry, often requiring appropriate catalysts and solvent systems compatible with sensitive ligands. Reaction design should prioritize maintaining ligand integrity and minimizing side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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