Thiol-PEG4-propionic acid
CAS No.: 749247-06-1
Cat No.: BP-501310
Purity: >95%
4.5 
Thiol-PEG4-propionic acid is a heterobifunctional PEG-based linker featuring a terminal thiol for chemoselective conjugation and a terminal propionic acid for subsequent coupling or anchor formation. Structurally, it provides a short, flexible polyethylene glycol spacer that can improve solubility and reduce steric constraints between a PROTAC ligand and a second binding module. In targeted protein degradation workflows, the thiol handle enables controlled attachment to electrophilic partners (for example, maleimide- or haloacetamide-functionalized moieties) to generate stable conjugates, while the carboxylic acid functionality can be used to form amide or other acyl linkages during PROTAC assembly. Its PEG4 length and flexible chain help maintain productive geometry for ternary complex formation, thereby supporting efficient recruitment of the target protein by the E3 ligase–binding component. This linker is valuable for researchers optimizing conjugation chemistry and linker effects on degradation potency and selectivity.
Structure of 749247-06-1
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Thiol-PEG4-propionic acid is a PEG-based bifunctional linker designed for constructing PROTACs and related targeted protein degradation conjugates. Its thiol handle enables robust attachment strategies to electrophilic partners, while the terminal carboxylic acid supports stable coupling to amine-bearing ligands or activated ester intermediates. The PEG chain provides beneficial solubility and spatial flexibility to help tune ternary complex formation. Detailed structural and reactivity considerations are provided below.
Structure: The molecule contains a poly(ethylene glycol) segment linked to a propionic acid motif and a terminal thiol group. It features ether linkages within the PEG backbone, a carboxylic acid functionality, and a thiol capable of forming thioether or disulfide linkages under appropriate conditions. Overall, it is flexible, polar, and water-compatible.
Reactivity: The thiol can participate in nucleophilic substitution or thiol–Michael-type conjugations when suitable electrophiles are present, and it can also be used for disulfide exchange strategies when reversible connectivity is desired. The carboxylic acid is typically converted to activated esters or coupled via carbodiimide-mediated amide formation with amine-containing binding elements. Mild, oxygen-controlled conditions are commonly used to limit thiol oxidation; appropriate aqueous/organic cosolvent systems and standard coupling reagents are selected based on the electrophile and target functional group.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
