THP-PEG11-OH
Cat No.: BP-501808
4.5 
THP-PEG11-OH is a heterobifunctional PEG-based linker featuring a terminal hydroxyl group and a tetrahydropyranyl (THP) ether-protected terminus, designed to provide a flexible, water-compatible spacer for PROTAC assembly. The PEG11 chain length and ether chemistry impart conformational mobility and improved solubility, which can reduce steric interference between the target-binding ligand and the E3 ligase recruiter. In PROTAC constructs, such linkers serve as molecular “spacing elements” that tune effective intramolecular proximity, thereby supporting efficient formation of the ternary complex and promoting ubiquitination of the recruited protein. The THP ether functions as a protecting group for a hydroxyl terminus and can be removed under suitable acidic conditions, while the hydroxyl terminus enables straightforward conjugation or derivatization to introduce reactive handles for subsequent coupling steps. This product is valuable for researchers optimizing linker length, flexibility, and physicochemical properties to enhance targeted protein degradation performance in cellular assays.
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* For research and manufacturing use only. Not for human or clinical use.
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Popular Publications Citing BOC Sciences Products
THP-PEG11-OH is a polyethylene glycol (PEG)-based linker building block designed for constructing PROTACs that require improved solubility and controlled spatial presentation between a ligand and an E3-recruiting module. Its ether-rich PEG backbone supports flexible conformational behavior, which can enhance productive ternary complex formation in targeted protein degradation workflows. The detailed Structure and Reactivity parameters are provided below.
Structure: THP-PEG11-OH contains a THP-protected hydroxyl handle linked to an extended PEG chain featuring multiple ether linkages. The molecule is characterized by flexible C–O and C–C connectivity, a terminal hydroxyl functionality, and a polar, hydrogen-bonding capable ether network that promotes aqueous compatibility.
Reactivity: The terminal hydroxyl enables standard linker-to-ligand conjugation strategies commonly used in PROTAC synthesis, including activation to form electrophiles for nucleophilic substitution or coupling with appropriately functionalized partners. PEG ether backbones are generally stable under mild organic conditions; THP protection is typically removed under acid-mediated deprotection conditions to reveal the reactive alcohol for subsequent coupling steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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