PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-200713	5-(6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide	2185795-64-4	CRBN	BRD4	Inquiry
Molecular Weight: 674.76 Molecular Formula: C38H38N6O6 Boiling Point: 920.7±65.0°C at 760 Torr Melting Point: 148-150°C Density: 1.331±0.06 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200714	6-(6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide	2185795-65-5	CRBN	BRD4	Inquiry
Molecular Weight: 688.79 Molecular Formula: C39H40N6O6 Boiling Point: 924.6±65.0°C at 760 Torr Melting Point: 140-142°C Density: 1.316±0.06 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200715	7-(6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)heptanamide	2185795-66-6	CRBN	BRD4	Inquiry
Molecular Weight: 702.81 Molecular Formula: C40H42N6O6 Boiling Point: 928.7±65.0°C at 760 Torr Melting Point: 136-138°C Density: 1.302±0.06 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200716	2-(2-(2-(4-((6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide	2185795-54-2	CRBN	BRD4	Inquiry
Molecular Weight: 801.86 Molecular Formula: C42H43N9O8 Melting Point: 165-167°C Density: 1.46±0.1 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200717	2-(2-(2-(2-(4-((6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide	2185795-55-3	CRBN	BRD4	Inquiry
Molecular Weight: 845.91 Molecular Formula: C44H47N9O9 Melting Point: 154-156°C Density: 1.44±0.1 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200718	14-(4-((6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide	2185795-56-4	CRBN	BRD4	Inquiry
Molecular Weight: 889.97 Molecular Formula: C46H51N9O10 Melting Point: 143-145°C Density: 1.42±0.1 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200719	2-(2-(2-(4-((6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide	2133360-01-5	CRBN	BRD4	Inquiry
Molecular Weight: 815.84 Molecular Formula: C42H41N9O9 Melting Point: 147-149°C Density: 1.49±0.1 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200720	2-(2-(2-(2-(4-((6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide	2133360-02-6	CRBN	BRD4	Inquiry
Molecular Weight: 859.90 Molecular Formula: C44H45N9O10 Melting Point: 142-144°C Density: 1.47±0.1 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200721	14-(4-((6-(3,5-Dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide	2133360-03-7	CRBN	BRD4	Inquiry
Molecular Weight: 903.95 Molecular Formula: C46H49N9O11 Melting Point: 135-137°C Density: 1.45±0.1 g/cm3 Description: It is a PROTAC BRD4 degrader based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
	BPL-200722	(2S,4R)-N-(2-(2-(2-(2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide	2375564-53-5	VHL	PBRM1 SMARCA2 SMARCA4	Inquiry
Molecular Weight: 918.11 Molecular Formula: C46H60FN9O8S Boiling Point: 1116.2±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1.
	BPL-200723	(2S,4R)-N-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide	2375564-54-6	VHL	PBRM1 SMARCA2 SMARCA4	Inquiry
Molecular Weight: 920.13 Molecular Formula: C49H58FN9O6S Boiling Point: 1131.0±65.0°C at 760 Torr Density: 1.40±0.1 g/cm3 Description: It is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1.
	BPL-200724	THAL-NVP-2-02-099	2207587-84-4	CRBN	CDK9	Inquiry
Molecular Weight: 929.48 Molecular Formula: C46H57ClN10O9 Boiling Point: 1144.8±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is a selective CDK9 degrader.
	BPL-200725	THAL-NVP-2-03-069	2207587-85-5	CRBN	CDK9	Inquiry
Molecular Weight: 796.37 Molecular Formula: C42H50ClN9O5 Boiling Point: 1024.1±65.0°C at 760 Torr Density: 1.37±0.1 g/cm3 Description: It is a selective CDK9 degrader.
	BPL-200726	THAL-NVP-2-03-084	2207587-86-6	CRBN	CDK9	Inquiry
Molecular Weight: 853.43 Molecular Formula: C44H53ClN10O6 Boiling Point: 1111.6±65.0°C at 760 Torr Density: 1.38±0.1 g/cm3 Description: It is a selective CDK9 degrader.
	BPL-200727	THAL-NVP-2-03-105	2207587-87-7	CRBN	CDK9	Inquiry
Molecular Weight: 854.41 Molecular Formula: C44H52ClN9O7 Boiling Point: 1106.4±65.0°C at 760 Torr Density: 1.38±0.1 g/cm3 Description: It is a selective CDK9 degrader.
	BPL-200728	Lenalidomide-SLF	2384184-39-6	CRBN	FKBP12	Inquiry
Molecular Weight: 979.14 Molecular Formula: C53H66N6O12 Density: 1.276±0.06 g/cm3 Description: It is an electrophilic PROTAC that degrades nuclear proteins by engaging CRBN.
	BPL-200729	KB02-PEG0-SLF	2375197-63-8	DCAF16	FKBP12	Inquiry
Molecular Weight: 790.35 Molecular Formula: C43H52ClN3O9 Density: 1.252±0.06 g/cm3 Description: It is an electrophilic PROTAC that degrades nuclear proteins by engaging DCAF16.
	BPL-200730	KB02-PEG4-SLF	2384184-45-4	DCAF16	FKBP12	Inquiry
Molecular Weight: 1037.65 Molecular Formula: C54H73ClN4O14 Density: 1.229±0.06 g/cm3 Description: It is an electrophilic PROTAC that degrades nuclear proteins by engaging DCAF16.
	BPL-200731	4-((S)-15-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-16,16-dimethyl-13-oxo-4,7,10-trioxa-14-azaheptadec-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide	2374122-18-4	VHL	IRAK4	Inquiry
Molecular Weight: 942.11 Molecular Formula: C48H59N7O11S Boiling Point: 1180.7±65.0°C at 760 Torr Density: 1.36±0.1 g/cm3 Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
	BPL-200732	4-(13-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridec-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide	2374122-20-8	VHL	IRAK4	Inquiry
Molecular Weight: 936.19 Molecular Formula: C51H65N7O8S Boiling Point: 1158.9±65.0°C at 760 Torr Density: 1.29±0.1 g/cm3 Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.