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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
4-(3-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)prop-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide BPL-200733 4-(3-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)prop-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide 2374122-22-0

CRBN

IRAK4

 Inquiry

Molecular Weight: 757.75

Molecular Formula: C38H39N5O12

Boiling Point: 1036.5±65.0°C at 760 Torr

Density: 1.47±0.1 g/cm3

Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
4-(12-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)dodec-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide BPL-200734 4-(12-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)dodec-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide 2374122-23-1

CRBN

IRAK4

 Inquiry

Molecular Weight: 751.84

Molecular Formula: C41H45N5O9

Boiling Point: 1003.9±65.0°C at 760 Torr

Density: 1.37±0.1 g/cm3

Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
4-(3-(2-(2-(3-(((3S,5S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)amino)-3-oxopropoxy)ethoxy)ethoxy)prop-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide BPL-200735 4-(3-(2-(2-(3-(((3S,5S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)amino)-3-oxopropoxy)ethoxy)ethoxy)prop-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide 2374122-24-2

XIAP

IRAK4

 Inquiry

Molecular Weight: 995.19

Molecular Formula: C53H70N8O11

Boiling Point: 1230.3±65.0°C at 760 Torr

Density: 1.31±0.1 g/cm3

Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
4-(13-(((3S,5S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)amino)-13-oxotridec-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide BPL-200736 4-(13-(((3S,5S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)amino)-13-oxotridec-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide 2374122-25-3

XIAP

IRAK4

 Inquiry

Molecular Weight: 989.27

Molecular Formula: C56H76N8O8

Boiling Point: 1209.7±65.0°C at 760 Torr

Density: 1.25±0.1 g/cm3

Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
1-(((2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridec-1-yn-1-yl)-7-methoxyisoquinoline-6-carboxamide BPL-200737 1-(((2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridec-1-yn-1-yl)-7-methoxyisoquinoline-6-carboxamide 2573979-80-1

VHL

IRAK4

 Inquiry

Molecular Weight: 982.23

Molecular Formula: C53H68FN7O8S

Boiling Point: 1159.7±65.0°C at 760 Torr

Density: 1.29±0.1 g/cm3

Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
1-(((2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(3-(9-(5-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)pyrimidin-2-yl)-3,9-diazaspiro[5.5]undecan-3-yl)prop-1-yn-1-yl)-7-methoxyisoquinoline-6-carboxamide BPL-200738 1-(((2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(3-(9-(5-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)pyrimidin-2-yl)-3,9-diazaspiro[5.5]undecan-3-yl)prop-1-yn-1-yl)-7-methoxyisoquinoline-6-carboxamide 2374122-27-5

VHL

IRAK4

 Inquiry

Molecular Weight: 1086.31

Molecular Formula: C57H68FN11O8S

Density: 1.40±0.1 g/cm3

Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
HBL-4 BPL-200739 HBL-4 2382972-50-9

CRBN

BRD4
PLK1

 Inquiry

Molecular Weight: 811.90

Molecular Formula: C41H49N9O9

Density: 1.369±0.06 g/cm3

Description: It is a PROTAC that targets bromodomain 4 (BRD4) and Polo-like kinase 1 (PLK1) proteins in acute myeloid leukemia cells.
HBL-5 BPL-200740 HBL-5

CRBN

BRD4
PLK1

 Inquiry

Molecular Weight: 900.00

Molecular Formula: C45H57N9O11

Description: It is a PROTAC that targets bromodomain 4 (BRD4) and Polo-like kinase 1 (PLK1) proteins in acute myeloid leukemia cells.
β-NF-ATRA BPL-200741 β-NF-ATRA 2416251-59-5

AhR

CRABP-I
CRABP-II

 Inquiry

Molecular Weight: 802.97

Molecular Formula: C48H54N2O9

Density: 1.15±0.1 g/cm3

Description: β-NF-ATRA, a chimeric degrader directed against cellular retinoic acid binding proteins (CRABPs), induces AhR-dependent degradation of CRABP-1 and CRABP-2 via the ubiquitin-proteasome pathway.
α-NF-ATRA BPL-200742 α-NF-ATRA 2380003-93-8

AhR

CRABP-I
CRABP-II

 Inquiry

Molecular Weight: 802.97

Molecular Formula: C48H54N2O9

Density: 1.15±0.1 g/cm3

Description: alpha-NF-ATRA, a chimeric degrader directed against cellular retinoic acid binding proteins (CRABPs), induces AhR-dependent degradation of CRABP-1 and CRABP-2 via the ubiquitin-proteasome pathway.
ITE-ATRA BPL-200743 ITE-ATRA 2416251-60-8

AhR

CRABP-I
CRABP-II

 Inquiry

Molecular Weight: 771.94

Molecular Formula: C41H49N5O8S

Density: 1.24±0.1 g/cm3

Description: ITE-ATRA, a chimeric degrader directed against cellular retinoic acid binding proteins (CRABPs), induces AhR-dependent degradation of CRABP-1 and CRABP-2 via the ubiquitin-proteasome pathway.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200744 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461911-89-5

VHL

ER

 Inquiry

Molecular Weight: 993.18

Molecular Formula: C54H52N6O9S2

Density: 1.38±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200745 (2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461912-40-1

VHL

ER

 Inquiry

Molecular Weight: 1021.23

Molecular Formula: C56H56N6O9S2

Density: 1.35±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(5-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200746 (2S,4R)-4-Hydroxy-1-((S)-2-(5-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461946-53-0

VHL

ER

 Inquiry

Molecular Weight: 1035.26

Molecular Formula: C57H58N6O9S2

Density: 1.34±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)hexanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200747 (2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)hexanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461947-40-8

VHL

ER

 Inquiry

Molecular Weight: 1049.29

Molecular Formula: C58H60N6O9S2

Density: 1.33±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(7-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)heptanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200748 (2S,4R)-4-Hydroxy-1-((S)-2-(7-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)heptanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461947-93-1

VHL

ER

 Inquiry

Molecular Weight: 1063.31

Molecular Formula: C59H62N6O9S2

Density: 1.33±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(8-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)octanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200749 (2S,4R)-4-Hydroxy-1-((S)-2-(8-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)octanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461948-42-3

VHL

ER

 Inquiry

Molecular Weight: 1077.34

Molecular Formula: C60H64N6O9S2

Density: 1.32±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200750 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461948-95-6

VHL

ER

 Inquiry

Molecular Weight: 1037.23

Molecular Formula: C56H56N6O10S2

Density: 1.36±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200751 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461949-60-8

VHL

ER

 Inquiry

Molecular Weight: 1081.28

Molecular Formula: C58H60N6O11S2

Density: 1.35±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200752 (2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2461950-13-8

VHL

ER

 Inquiry

Molecular Weight: 1125.34

Molecular Formula: C60H64N6O12S2

Density: 1.34±0.1 g/cm3

Description: It is a potent ER degrader.

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