| Structure |
Catalog |
Product Name |
CAS |
E3 Ligase |
Target |
Inquiry |
 |
BPL-200733 |
4-(3-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)prop-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide |
2374122-22-0 |
CRBN |
IRAK4 |
Inquiry |
|
Molecular Weight: 757.75
Molecular Formula: C38H39N5O12
Boiling Point: 1036.5±65.0°C at 760 Torr
Density: 1.47±0.1 g/cm3
Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
|
 |
BPL-200734 |
4-(12-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)dodec-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide |
2374122-23-1 |
CRBN |
IRAK4 |
Inquiry |
|
Molecular Weight: 751.84
Molecular Formula: C41H45N5O9
Boiling Point: 1003.9±65.0°C at 760 Torr
Density: 1.37±0.1 g/cm3
Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
|
 |
BPL-200735 |
4-(3-(2-(2-(3-(((3S,5S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)amino)-3-oxopropoxy)ethoxy)ethoxy)prop-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide |
2374122-24-2 |
XIAP |
IRAK4 |
Inquiry |
|
Molecular Weight: 995.19
Molecular Formula: C53H70N8O11
Boiling Point: 1230.3±65.0°C at 760 Torr
Density: 1.31±0.1 g/cm3
Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
|
 |
BPL-200736 |
4-(13-(((3S,5S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)amino)-13-oxotridec-1-yn-1-yl)-7-methoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide |
2374122-25-3 |
XIAP |
IRAK4 |
Inquiry |
|
Molecular Weight: 989.27
Molecular Formula: C56H76N8O8
Boiling Point: 1209.7±65.0°C at 760 Torr
Density: 1.25±0.1 g/cm3
Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
|
 |
BPL-200737 |
1-(((2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridec-1-yn-1-yl)-7-methoxyisoquinoline-6-carboxamide |
2573979-80-1 |
VHL |
IRAK4 |
Inquiry |
|
Molecular Weight: 982.23
Molecular Formula: C53H68FN7O8S
Boiling Point: 1159.7±65.0°C at 760 Torr
Density: 1.29±0.1 g/cm3
Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
|
![1-(((2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(3-(9-(5-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)pyrimidin-2-yl)-3,9-diazaspiro[5.5]undecan-3-yl)prop-1-yn-1-yl)-7-methoxyisoquinoline-6-carboxamide](https://resource.bocsci.com/structure/2374122-27-5.gif) |
BPL-200738 |
1-(((2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(3-(9-(5-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)pyrimidin-2-yl)-3,9-diazaspiro[5.5]undecan-3-yl)prop-1-yn-1-yl)-7-methoxyisoquinoline-6-carboxamide |
2374122-27-5 |
VHL |
IRAK4 |
Inquiry |
|
Molecular Weight: 1086.31
Molecular Formula: C57H68FN11O8S
Density: 1.40±0.1 g/cm3
Description: It is an IRAK4 Proteolysis Targeted Chimera (PROTAC) that induces IRAK4 degradation.
|
 |
BPL-200739 |
HBL-4 |
2382972-50-9 |
CRBN |
BRD4
PLK1 |
Inquiry |
|
Molecular Weight: 811.90
Molecular Formula: C41H49N9O9
Density: 1.369±0.06 g/cm3
Description: It is a PROTAC that targets bromodomain 4 (BRD4) and Polo-like kinase 1 (PLK1) proteins in acute myeloid leukemia cells.
|
 |
BPL-200740 |
HBL-5 |
|
CRBN |
BRD4
PLK1 |
Inquiry |
|
Molecular Weight: 900.00
Molecular Formula: C45H57N9O11
Description: It is a PROTAC that targets bromodomain 4 (BRD4) and Polo-like kinase 1 (PLK1) proteins in acute myeloid leukemia cells.
|
 |
BPL-200741 |
β-NF-ATRA |
2416251-59-5 |
AhR |
CRABP-I
CRABP-II |
Inquiry |
|
Molecular Weight: 802.97
Molecular Formula: C48H54N2O9
Density: 1.15±0.1 g/cm3
Description: β-NF-ATRA, a chimeric degrader directed against cellular retinoic acid binding proteins (CRABPs), induces AhR-dependent degradation of CRABP-1 and CRABP-2 via the ubiquitin-proteasome pathway.
|
 |
BPL-200742 |
α-NF-ATRA |
2380003-93-8 |
AhR |
CRABP-I
CRABP-II |
Inquiry |
|
Molecular Weight: 802.97
Molecular Formula: C48H54N2O9
Density: 1.15±0.1 g/cm3
Description: alpha-NF-ATRA, a chimeric degrader directed against cellular retinoic acid binding proteins (CRABPs), induces AhR-dependent degradation of CRABP-1 and CRABP-2 via the ubiquitin-proteasome pathway.
|
 |
BPL-200743 |
ITE-ATRA |
2416251-60-8 |
AhR |
CRABP-I
CRABP-II |
Inquiry |
|
Molecular Weight: 771.94
Molecular Formula: C41H49N5O8S
Density: 1.24±0.1 g/cm3
Description: ITE-ATRA, a chimeric degrader directed against cellular retinoic acid binding proteins (CRABPs), induces AhR-dependent degradation of CRABP-1 and CRABP-2 via the ubiquitin-proteasome pathway.
|
![(2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461911-89-5.gif) |
BPL-200744 |
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461911-89-5 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 993.18
Molecular Formula: C54H52N6O9S2
Density: 1.38±0.1 g/cm3
Description: It is a potent ER degrader.
|
![(2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461912-40-1.gif) |
BPL-200745 |
(2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461912-40-1 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 1021.23
Molecular Formula: C56H56N6O9S2
Density: 1.35±0.1 g/cm3
Description: It is a potent ER degrader.
|
![(2S,4R)-4-Hydroxy-1-((S)-2-(5-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461946-53-0.gif) |
BPL-200746 |
(2S,4R)-4-Hydroxy-1-((S)-2-(5-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461946-53-0 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 1035.26
Molecular Formula: C57H58N6O9S2
Density: 1.34±0.1 g/cm3
Description: It is a potent ER degrader.
|
![(2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)hexanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461947-40-8.gif) |
BPL-200747 |
(2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)hexanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461947-40-8 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 1049.29
Molecular Formula: C58H60N6O9S2
Density: 1.33±0.1 g/cm3
Description: It is a potent ER degrader.
|
![(2S,4R)-4-Hydroxy-1-((S)-2-(7-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)heptanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461947-93-1.gif) |
BPL-200748 |
(2S,4R)-4-Hydroxy-1-((S)-2-(7-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)heptanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461947-93-1 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 1063.31
Molecular Formula: C59H62N6O9S2
Density: 1.33±0.1 g/cm3
Description: It is a potent ER degrader.
|
![(2S,4R)-4-Hydroxy-1-((S)-2-(8-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)octanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461948-42-3.gif) |
BPL-200749 |
(2S,4R)-4-Hydroxy-1-((S)-2-(8-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)octanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461948-42-3 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 1077.34
Molecular Formula: C60H64N6O9S2
Density: 1.32±0.1 g/cm3
Description: It is a potent ER degrader.
|
![(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461948-95-6.gif) |
BPL-200750 |
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461948-95-6 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 1037.23
Molecular Formula: C56H56N6O10S2
Density: 1.36±0.1 g/cm3
Description: It is a potent ER degrader.
|
![(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461949-60-8.gif) |
BPL-200751 |
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(2-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461949-60-8 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 1081.28
Molecular Formula: C58H60N6O11S2
Density: 1.35±0.1 g/cm3
Description: It is a potent ER degrader.
|
![(2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2461950-13-8.gif) |
BPL-200752 |
(2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-((2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
2461950-13-8 |
VHL |
ER |
Inquiry |
|
Molecular Weight: 1125.34
Molecular Formula: C60H64N6O12S2
Density: 1.34±0.1 g/cm3
Description: It is a potent ER degrader.
|
