CAS No.: 2064292-52-8 Cat No.: BP-100013 Purity: ≥98%4.5
VH 032 Linker 2 is an advanced E3 Ligase Ligand-Linker Conjugate designed to facilitate the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound combines the potent VH 032 moiety, a recognized ligand for the Von Hippel-Lindau (VHL) E3 ligase, with an optimized linker segment, making it ideal for creating bifunctional molecules that induce targeted protein degradation. PROTAC technology leverages the recruitment of E3 ligases to ubiquitinate and degrade disease-related proteins, offering a novel therapeutic strategy for otherwise 'undruggable' targets. VH 032 Linker 2 serves as a vital building block in the synthesis of custom PROTAC constructs for cancer research, neurodegenerative diseases, and other emerging biomedical applications, supporting researchers focused on next-generation targeted protein degradation modalities.
Structure of 2064292-52-8
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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C32H50ClN5O8S
Molecular Weight
700.289
* For research and manufacturing use only. Not for human or clinical use.
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VH 032 Linker 2 is a specialized E3 ligase ligand-linker conjugate designed for the development of PROTACs (Proteolysis Targeting Chimeras). PROTAC technology utilizes bifunctional molecules to harness the ubiquitin-proteasome system for targeted protein degradation, offering a novel therapeutic approach to address previously 'undruggable' proteins. VH 032 is a well-established ligand for the E3 ligase VHL (von Hippel-Lindau), making this product highly valuable for researchers in drug discovery.
Mechanism
VH 032 Linker 2 functions as a modular component for PROTAC synthesis. It features a VH 032 moiety, which binds specifically to the VHL E3 ubiquitin ligase. The attached linker segment provides chemical handle(s) for conjugation to a ligand targeting the protein of interest. When integrated into a PROTAC molecule, VH 032 Linker 2 facilitates the recruitment of both the E3 ligase and the target protein, leading to ubiquitination and subsequent proteasomal degradation of the target protein.
Applications
VH 032 Linker 2 is ideal for researchers developing new PROTAC molecules aimed at selective protein degradation. Applications include creating targeted small molecule degraders for cancer, neurodegenerative diseases, and other therapeutic areas. Its proven efficacy as a VHL E3 ligand makes it invaluable for medicinal chemistry workflows, preclinical studies, and translational research focused on harnessing the power of targeted protein degradation technology.
• Optimized VH032-based linker ensures high binding affinity to VHL E3 ligase, improving PROTAC potency and selectivity.
• Versatile linker design enables efficient conjugation to diverse warheads, supporting flexible PROTAC development for targeted protein degradation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
CAS No.: 2064292-52-8
Purity: ≥98%
