3-(2-Carboxyethoxy)propanoic acid
CAS No.: 5961-83-1
Cat No.: BP-501597
Purity: 95%
4.5 
3-(2-Carboxyethoxy)propanoic acid is a bifunctional aliphatic linker bearing two carboxylic acid groups connected through an ether-containing spacer, providing a flexible, hydrophilic chain suitable for conjugation chemistry. Structurally, it offers a terminal carboxyl group for coupling to one PROTAC module (e.g., a ligand or warhead) and a second carboxyl group that can be activated for attachment to the complementary module, enabling construction of degraders with controlled spatial separation. In PROTAC design, such linkers help tune the effective distance and relative orientation between the target-binding ligand and the E3 ligase recruiter, which can strongly influence ternary complex formation and downstream ubiquitination efficiency. As a research-grade building block, it is valuable for preparing linker variants for systematic structure–activity studies, facilitating reproducible synthesis of targeted protein degradation constructs and supporting optimization of solubility and linker flexibility in vitro.
Structure of 5961-83-1
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
3-(2-Carboxyethoxy)propanoic acid, provides a chemically versatile, carboxylate-rich scaffold suitable for constructing bifunctional degraders. Its functional groups enable robust conjugation strategies that support controlled spatial presentation of ligands in targeted protein degradation workflows. The linker’s hydrophilic character and multiple reactive handles can improve coupling efficiency and compatibility with common PROTAC assembly sequences. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains a propanoic acid core bearing an ether-linked carboxyethoxy substituent, providing two carboxylic acid functionalities and an internal ether linkage. The molecule features polar O–H and C–O bonds, with a flexible aliphatic backbone that supports conformational adaptability.
Reactivity: For PROTAC synthesis, the carboxylic acids are typically activated toward amide or ester bond formation using standard coupling chemistries, such as carbodiimide-based activation with appropriate additives, or acid chloride formation under controlled conditions. Reactions are commonly performed in polar aprotic solvents with base to promote nucleophilic acyl substitution. The flexible ether-containing scaffold can be retained during coupling, while protecting-group strategies may be used to achieve selective functionalization when both acids are present.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
