Amino-PEG12-CH2COOH
Cat No.: BP-502030
4.5 
Amino-PEG12-CH2COOH is a polyethylene glycol (PEG) linker featuring a terminal primary amine and a carboxymethyl group, enabling robust conjugation chemistry for PROTAC construction. Structurally, it provides a flexible, hydrophilic spacer with an extended PEG chain length that can reduce steric interference between the two binding modules of a PROTAC and help maintain productive geometry for ternary complex formation. In targeted protein degradation designs, this linker is typically used to connect a ligand that recruits an E3 ligase to a ligand or warhead that binds the target protein, while the terminal functional groups allow straightforward coupling to activated carboxylates or electrophiles. The PEG-based architecture can improve solubility and often enhances the practical handling of conjugates during synthesis and purification. As a modular, chemically addressable linker, Amino-PEG12-CH2COOH is valuable for systematic optimization of linker length and flexibility in targeted degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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Amino-PEG12-CH2COOH is a polyethylene glycol-based PROTAC linker designed to provide a flexible, hydrophilic spacer between a ligand and an E3-recruiting or target-binding moiety. Its terminal amino group enables robust conjugation strategies, while the carboxylic acid supports controlled coupling to complementary functional groups. Such linkers are widely used in targeted protein degradation to tune linker length, solubility, and effective spatial presentation of binding elements. The detailed structural and reactivity considerations are provided below.
Structure: The linker contains a PEG oligomer segment that confers conformational flexibility and strong water compatibility, connected to an amino terminus and a terminal carboxymethyl (CH2COOH) group. It features ether linkages within the PEG chain and a primary amine plus a carboxylic acid at the termini, enabling versatile bioconjugation chemistry.
Reactivity: The amino group can be used for amide-bond formation with activated carboxylic acids (for example, using common peptide-coupling reagents) or for carbamate/urea-forming routes depending on the electrophile. The terminal carboxylic acid is suitable for activation to form acylating intermediates that react with amines under standard coupling conditions. Typical approaches employ polar aprotic solvents, mild base, and temperature-controlled activation to preserve sensitive ligands during PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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