Amino-PEG14-acid
Cat No.: BP-501774
4.5 
Amino-PEG14-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal primary amine and a terminal carboxylic acid, connected through an extended PEG chain of approximately fourteen ethylene glycol units. The flexible, hydrophilic PEG backbone provides a long, solvent-accessible spacer that can reduce steric interference between a targeting ligand and an E3 ligase-binding moiety in PROTAC constructs. In targeted protein degradation design, the terminal amine is commonly used for amide coupling, reductive amination, or other conjugation strategies to attach one PROTAC component, while the terminal carboxylic acid enables complementary coupling to the remaining component or to handles for further functionalization. This linker’s combination of reactive termini and conformational flexibility helps maintain productive ternary complex formation and can improve solubility and handling of conjugates during synthesis and biological evaluation.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG14-acid is a polyethylene glycol (PEG)-based linker designed to support PROTAC assembly by providing a hydrophilic, flexible spacer and a terminal carboxylic acid for controlled conjugation. Its amino functionality enables orthogonal coupling strategies, facilitating the construction of bifunctional degraders that can efficiently bring target ligands into proximity with an E3 ligase. The detailed structural and synthetic considerations are provided below.
Structure: The linker comprises a PEG chain that offers conformational flexibility and strong water compatibility, terminated by an amino group and a carboxylic acid. It contains multiple ether linkages characteristic of PEG, with functional groups suitable for amide or ester formation and for salt-state tuning.
Reactivity: For PROTAC synthesis, the carboxylic acid is typically activated to form an amide or related conjugates using standard coupling chemistries, followed by reaction with an appropriate amine-bearing partner. The amino terminus can be used for orthogonal coupling when protected or selectively activated. Common approaches employ peptide-coupling reagents in polar aprotic solvents under mild base conditions to drive efficient bond formation while minimizing side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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