Amino-PEG15-amine
Cat No.: BP-502084
Purity: >95%
4.5 
Amino-PEG15-amine is a bifunctional polyethylene glycol linker bearing terminal primary amines, providing a flexible, hydrophilic spacer for conjugation in PROTAC and targeted protein degradation constructs. Structurally, it consists of a PEG chain of intermediate length that can adopt multiple conformations, helping to reduce steric clashes between the ligand-binding moieties while maintaining sufficient reach for productive ternary complex formation. In PROTAC design, the two amine termini enable straightforward coupling to complementary reactive groups on the E3 ligase ligand and the target-binding ligand, thereby positioning these components to promote ubiquitination-dependent degradation. The PEG scaffold also improves aqueous solubility and can mitigate aggregation, which is often critical for evaluating degradation potency and kinetics in cell-based assays. As a modular, chemically tractable spacer, Amino-PEG15-amine is valuable for systematic linker optimization to balance flexibility, distance, and cellular performance in targeted degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG15-amine is a polyethylene glycol-based bifunctional linker designed for assembling PROTACs and other targeted protein degradation constructs. Its flexible, hydrophilic spacer supports productive ternary complex formation by reducing steric constraints between the ligand warheads. The amine termini enable straightforward conjugation strategies, facilitating modular synthesis and optimization of degradation potency and selectivity. The structure and reactivity considerations for PROTAC building with this linker are described in detail below.
Structure: Amino-PEG15-amine contains a repeating ethylene glycol backbone providing high polarity and conformational flexibility. Two terminal primary amines serve as reactive handles, while ether linkages dominate the scaffold. The linker is typically water-compatible and can enhance solubility and reduce nonspecific hydrophobic interactions in conjugates.
Reactivity: The terminal amines are suitable for standard PROTAC coupling chemistries such as amide bond formation via activated carboxylic acids, carbamate formation using activated carbonyl reagents, or reductive amination with aldehyde-bearing partners. Commonly used conditions involve mild bases and polar aprotic solvents, with coupling reagents selected to minimize side reactions. Linker–ligand conjugation generally proceeds through nucleophilic acyl substitution or imine/intermediate formation followed by reduction.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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