Amino-PEG20-acid
Cat No.: BP-501793
4.5 
Amino-PEG20-acid is a heterobifunctional PEG-based linker featuring a terminal amino group for covalent attachment to one PROTAC component and a terminal carboxylic acid for coupling to the second component. Structurally, it is a linear, hydrophilic polyethylene glycol chain of extended length that provides flexible spacing between conjugated partners while maintaining aqueous solubility and reducing steric interference. In PROTAC design, such PEG linkers act as molecular “spacers” that tune the effective distance and relative orientation between the ligand-binding moieties, thereby facilitating productive formation of the ternary complex with the target protein and the E3 ligase. The terminal functional groups enable robust amide or related coupling strategies to generate well-defined conjugates. This linker is valuable for targeted protein degradation research where linker length and flexibility strongly influence degradation potency, selectivity, and overall physicochemical properties of the resulting PROTACs.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG20-acid is a PEG-based PROTAC linker designed to provide a flexible, hydrophilic connection between target-binding ligands and to support efficient formation of ternary complexes. Its amino functionality enables robust conjugation strategies, while the terminal acid facilitates controlled coupling and purification workflows. The linker’s ether-rich scaffold helps reduce nonspecific hydrophobic interactions and can improve aqueous solubility of assembled degraders. Detailed structural and reactivity considerations are provided below.
Structure: Amino-PEG20-acid consists of a poly(ethylene glycol) chain terminated by an amino group and a carboxylic acid. The backbone contains repeating ether linkages, offering conformational flexibility and strong hydrogen-bonding capacity. The termini provide complementary functional handles for amide or related bond formation under standard bioconjugation conditions.
Reactivity: The amino group can be used to form amide or urea linkages with activated carboxylic acids or carboxyl-derivatives, commonly via carbodiimide-mediated coupling or activated ester chemistry. The carboxylic acid can be converted to reactive intermediates (for example, acid chlorides or activated esters) prior to nucleophilic substitution by amines. Typical conditions employ polar aprotic solvents and base/acid catalysts compatible with PEG stability, with reaction monitoring by chromatography or analytical MS.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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