Amino-PEG20-Boc
Cat No.: BP-501777
4.5 
Amino-PEG20-Boc is a polyethylene glycol (PEG) linker bearing a terminal primary amine and a Boc-protected group, providing a flexible, hydrophilic spacer with a long chain length suitable for PROTAC synthesis and other bioconjugation workflows. The PEG backbone imparts conformational mobility and aqueous solubility, which can reduce steric clashes between the target-binding ligand and the E3 ligase-recruiting moiety, thereby improving the probability of productive ternary complex formation. The terminal amine enables coupling to activated carboxyl groups, NHS esters, or other electrophiles, while Boc protection offers a controlled handle for stepwise assembly and subsequent deprotection under standard conditions. In targeted protein degradation research, such linkers are valuable for tuning linker length, polarity, and effective reach between binding domains, supporting systematic optimization of PROTAC potency and selectivity.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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Amino-PEG20-Boc is a protected, PEG-based bifunctional linker designed to support the modular synthesis of PROTACs and related targeted protein degradation constructs. Its PEG segment provides aqueous compatibility and conformational flexibility, while the tert-butyl ester-protected carboxyl group enables controlled functional-group handling during stepwise conjugation. The amino functionality supports coupling to ligands or warheads, facilitating efficient assembly of degraders. The following points describe the linker’s structure and practical reactivity considerations in PROTAC workflows.
Structure: Amino-PEG20-Boc contains a polyethylene glycol chain bearing a terminal amino group and a tert-butyl ester-protected carboxyl group. The linker features repeating ether linkages that confer hydrophilicity and segmental flexibility, along with ester functionality at the tert-butyl-protected carboxyl group. These elements support stable, water-compatible linker behavior in conjugation chemistry.
Reactivity: The terminal primary amine is already available for coupling, while the tert-butyl ester can be cleaved under mild acid conditions to reveal the carboxylic acid when needed. PROTAC assembly commonly uses amine-reactive coupling strategies such as carbodiimide-mediated amide formation or activated ester chemistry, depending on the partner functional group. Solvent systems are chosen to maintain PEG solubility, and coupling is generally performed under controlled pH to preserve linker integrity and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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