Aminooxy-PEG3-Aminooxy
CAS No.: 98627-70-4
Cat No.: BP-501423
Purity: ≥95%
4.5 
Aminooxy-PEG3-Aminooxy is a bifunctional, short-chain polyethylene glycol linker bearing two aminooxy (–ONH2) reactive groups at its termini. The PEG3 backbone provides water solubility and conformational flexibility, while the aminooxy functionalities enable chemoselective oxime formation with carbonyl-containing partners such as aldehydes or ketones. In PROTAC and targeted protein degradation workflows, this linker is used to connect or “tune” the spatial relationship between a ligand (e.g., a warhead for a target protein) and an E3 ligase–recruiting moiety by forming stable oxime linkages under mild conditions. Its defined, symmetric bifunctional design supports modular assembly, helping researchers optimize linker length and geometry to improve ternary complex formation and degradation efficiency. As a practical PEG-based conjugation tool, it facilitates systematic structure–activity studies and reproducible synthesis of PROTAC analogs for mechanistic and optimization experiments.
Structure of 98627-70-4
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This Aminooxy-PEG3-Aminooxy linker is designed for modular PROTAC construction, providing two reactive aminooxy termini that can be used to connect complementary targeting and E3 ligase ligands. Its PEG-based spacing supports productive linker flexibility and solvent compatibility, which can improve conjugation efficiency and maintain favorable geometry for ternary complex formation. The following sections describe the linker’s structural features and practical reactivity considerations for experimental assembly of targeted protein degraders.
Structure: The linker contains a poly(ethylene glycol) segment flanked by two aminooxy functional groups. It features ether-rich PEG connectivity, flexible C–O and C–C framework elements, and terminal O–N bonds characteristic of aminooxy chemistry. Overall, it is expected to be hydrophilic and conformationally adaptable in polar media.
Reactivity: Aminooxy groups are commonly used in oxime ligation, where they react with carbonyl-containing partners under mildly acidic conditions to form stable oxime linkages. For PROTAC synthesis, the linker is typically coupled sequentially to aldehyde or ketone functional groups on ligands, often using compatible aqueous/organic solvent mixtures and controlled pH to drive condensation while limiting side reactions. No special catalysts are generally required beyond reaction-condition optimization.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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