APN-C3-PEG4-alkyne
CAS No.: 2183440-36-8
Cat No.: BP-501469
Purity: 98%
4.5 
APN-C3-PEG4-alkyne is a PEG-based PROTAC linker featuring a three-carbon (C3) spacer connected to a tetraethylene glycol–type PEG segment and terminated with a terminal alkyne handle. The linker’s flexible PEG chain provides conformational freedom and improved solubility, while the short C3 segment helps position the conjugated warhead and E3 ligase-binding moieties at an appropriate distance to promote productive ternary-complex formation. The terminal alkyne enables bioorthogonal conjugation strategies, most commonly copper-catalyzed azide–alkyne cycloaddition (CuAAC), allowing researchers to attach the linker to complementary partners such as azide-functionalized ligands or probes under mild conditions. In targeted protein degradation workflows, this modular architecture facilitates systematic tuning of linker length and geometry, which is critical for optimizing degradation potency, selectivity, and cellular activity. Overall, it is a practical building block for constructing and rapidly iterating PROTACs and related targeted degraders.
Structure of 2183440-36-8
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
APN-C3-PEG4-alkyne is a polyethylene glycol-based PROTAC linker designed to connect a ligand-bearing warhead to an E3-recruiting element through a terminal alkyne handle. Its PEG character promotes solubility and conformational flexibility, which can improve effective engagement of target proteins in ternary complex formation. The linker’s modular “click-ready” functionality supports robust, reproducible assembly of PROTAC constructs. Detailed structural and synthetic considerations are provided below.
Structure: The linker contains a PEG chain that provides hydrophilic character and flexible ether linkages, terminating in an alkyne for orthogonal coupling. Its composition supports stable carbon–carbon and carbon–heteroatom connectivity during PROTAC synthesis, with physicochemical behavior typical of PEGylated linker systems.
Reactivity: The terminal alkyne enables copper-catalyzed azide–alkyne cycloaddition for efficient conjugation to azide-functional partners, a widely used strategy in PROTAC build workflows. Typical conditions employ a copper catalyst system in suitable polar solvents, with base and ligand additives often used to control reaction rate and minimize side reactions. The mechanism proceeds via formation of a copper acetylide followed by cycloaddition to form a stable triazole linkage.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
