Azide-PEG16-alcohol
Cat No.: BP-501954
4.5 
Azide-PEG16-alcohol is a polyethylene glycol linker bearing a terminal azide group and a terminal primary alcohol, providing a chemically versatile, flexible spacer for PROTAC and targeted protein degradation constructs. Structurally, it comprises a long PEG chain that promotes aqueous solubility and reduces steric constraints between the two binding modules, while the azide enables bioorthogonal conjugation via copper-catalyzed or strain-promoted azide–alkyne cycloaddition to attach the linker to complementary handles on ligands or warheads. The terminal alcohol can serve as a functional group for further derivatization (e.g., conversion to activated esters or carbonate derivatives) to facilitate controlled attachment to other PROTAC components. In targeted degradation research, such PEG linkers help tune effective molarity, linker length, and conformational freedom, often improving ternary complex formation and degradation efficiency. This product is therefore valuable for systematic PROTAC optimization and for constructing modular degradation reagents under reproducible synthetic workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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Azide-PEG16-alcohol is a polyethylene glycol (PEG)-based bifunctional linker designed for modular PROTAC assembly, enabling efficient conjugation to targeting ligands and E3-recruiting moieties while providing conformational flexibility and improved solubility. Its terminal azide supports bioorthogonal click chemistry, and the terminal alcohol provides a practical handle for derivatization. The linker’s utility in PROTAC technology lies in facilitating reliable, high-yield attachment strategies that preserve functional group compatibility; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG oligomer backbone featuring multiple ether linkages, terminating in an azide group and a primary alcohol. This flexible, hydrophilic architecture supports solvent-mediated conformational freedom and reduces steric constraints during PROTAC synthesis.
Reactivity: The azide functionality is well suited for copper(I)-catalyzed azide–alkyne cycloaddition or related click approaches to connect to alkyne-bearing partners under standard click conditions. The terminal alcohol can be converted to activated derivatives (for example, carbonate/ester forms) for coupling to complementary nucleophiles. Typical procedures use inert atmosphere control when needed, with polar solvents compatible with PEG and click reagents.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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