Azido-PEG15-azide
Cat No.: BP-502076
Purity: >95%
4.5 
Azido-PEG15-azide is a homobifunctional polyethylene glycol linker bearing azide termini at both ends, providing a flexible, hydrophilic spacer of extended length. Structurally, it consists of a PEG chain that separates two reactive azide groups, enabling modular conjugation chemistry while minimizing steric interference and nonspecific hydrophobic interactions. In PROTAC and targeted protein degradation workflows, such PEG–azide linkers are commonly used to connect or distance a ligand-recruiting module from an E3 ligase-binding moiety, thereby tuning effective intramolecular geometry and improving productive ternary complex formation. The terminal azides can be selectively functionalized via bioorthogonal azide–alkyne cycloaddition or azide-based coupling strategies to attach complementary partners under conditions compatible with sensitive biomolecular ligands. This product is valuable for researchers optimizing linker length and flexibility in degradation constructs, facilitating systematic structure–activity relationship studies and improving the robustness of conjugation during PROTAC assembly.
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG15-azide is a bifunctional polyethylene glycol (PEG) linker designed for modular assembly of PROTACs and related targeted protein degradation constructs. Its two terminal azide groups enable reliable orthogonal conjugation to complementary reaction handles on ligands, facilitating controlled linker length selection and improved solubility and flexibility in ternary complex formation. The points below describe the linker’s structure and practical reactivity considerations for PROTAC synthesis in the laboratory.
Structure: The linker consists of an ethylene glycol repeat unit segment terminated by two azide functional groups. It contains ether linkages within the PEG backbone and azide moieties at both ends, providing a flexible, hydrophilic spacer with chemical stability under standard handling conditions.
Reactivity: The terminal azides are well suited for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, allowing attachment to alkyne-bearing ligands or handles. Use of appropriate catalysts and ligand-compatible solvents is typically required for efficient coupling, while minimizing conditions that could impair sensitive warheads. The reactions proceed via formation of a triazole linkage, enabling robust PROTAC assembly and purification workflows.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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