Azido-PEG35-amine
CAS No.: 2301851-71-6
Cat No.: BP-501286
4.5 
Azido-PEG35-amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a primary amine at the opposite end, providing a long, flexible hydrophilic spacer suitable for PROTAC assembly. The PEG chain length and ether-rich backbone help reduce steric congestion and improve solubility, while the azide enables bioorthogonal conjugation via copper-free azide–alkyne cycloaddition (click chemistry) to attach the linker to an alkyne-bearing ligand or warhead. The terminal amine can be used for amide coupling, reductive amination, or other derivatization strategies to connect to carboxylic acid–functionalized partners, allowing modular synthesis of targeted protein degraders. In PROTAC design, this linker architecture supports controlled spatial separation between the targeting moiety and the E3 ligase ligand, which can be critical for productive ternary complex formation and efficient ubiquitination. Researchers value Azido-PEG35-amine for its versatility, compatibility with common conjugation workflows, and its ability to tune linker-mediated geometry during iterative degradation optimization.
Structure of 2301851-71-6
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Azido-PEG35-amine is a polyethylene glycol-based PROTAC linker bearing a terminal azide and a primary amine, enabling modular assembly of targeted protein degraders. Its flexible PEG scaffold supports productive ternary-complex formation by improving solubility and reducing steric constraints between the ligand and the E3-recruiting or binding element. The azide handle supports bioorthogonal conjugation, while the amine enables complementary coupling strategies. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG chain terminating in an azide group and a primary amine, providing a flexible, hydrophilic tether. It contains ether linkages within the PEG backbone and functional groups suitable for conjugation, with an overall polar character that promotes aqueous compatibility and stable handling.
Reactivity: The azide group is typically used in copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition to connect PROTAC modules under mild, bioorthogonal conditions. The terminal amine can be coupled to activated carboxylic acids or activated esters using standard amide-forming chemistries. Commonly used solvents include polar aprotic or aqueous buffers, with base and coupling reagents selected to preserve sensitive ligands and maintain linker integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
