Azido-PEG8-THP
Cat No.: BP-501998
4.5 
Azido-PEG8-THP is an azide-terminated, polyethylene glycol–based linker bearing a tetrahydropyran (THP) functional group, providing a flexible, water-compatible spacer for PROTAC and targeted protein degradation constructs. The PEG segment offers conformational mobility and improved solubility, while the terminal azide enables bioorthogonal conjugation via strain-promoted or copper-catalyzed azide–alkyne cycloaddition, allowing efficient attachment to complementary handles on ligands or other PROTAC modules. The THP moiety can serve as a protected alcohol equivalent or a chemically addressable handle depending on the synthetic strategy, facilitating controlled assembly of multi-component degraders. In targeted degradation research, such linkers help optimize the geometric relationship between the E3 ligase-recruiting ligand and the target-binding moiety, which is critical for productive ternary complex formation and degradation potency. This product is therefore valuable for constructing modular PROTAC libraries and systematically tuning linker length and reactivity during experimental optimization.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
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Popular Publications Citing BOC Sciences Products
Azido-PEG8-THP is a PEG-based PROTAC linker designed to enable robust conjugation between a ligand and a targeting module while providing conformational flexibility and improved solubility typical of polyethylene glycol architectures. The azide handle supports bioorthogonal “click” coupling, and the THP functionality provides a protected alcohol motif that can be leveraged during linker assembly. The advantages of this linker include modular synthesis, reliable functional-group compatibility, and suitability for constructing degraders that require precise spatial presentation. Detailed structural and reactivity guidance is provided below.
Structure: The linker contains an azide functional group and an extended PEG chain that confers flexibility, along with an THP (tetrahydropyranyl) protecting-group motif. It features ether linkages characteristic of PEG, and a terminal azide suitable for cycloaddition chemistry. Overall, it is designed to balance polarity and reactive handle stability.
Reactivity: The azide group is typically used in copper-free or copper-catalyzed azide–alkyne cycloaddition to attach to alkyne-bearing partners under mild conditions. THP-protected alcohol functionality is generally compatible with standard coupling steps and can be deprotected using mild acid to reveal the free alcohol for subsequent ester or ether formation. Solvent systems commonly favor organic–aqueous compatibility, and reaction design should preserve azide integrity and avoid strongly nucleophilic or reducing conditions that can interfere with azide chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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