Benzyl-PEG4-MS
CAS No.: 477781-69-4
Cat No.: BP-501550
Purity: >95%
4.5 
Benzyl-PEG4-MS is a heterobifunctional polyethylene glycol linker designed for PROTAC and related targeted protein degradation constructs, featuring a benzyl capping group connected through a short, flexible PEG chain (four ethylene glycol units) to a maleimide (MS) reactive handle. The PEG segment provides aqueous solubility and conformational flexibility, helping the degrader components adopt productive orientations while reducing steric penalties at the ternary complex interface. The maleimide group enables chemoselective conjugation to thiol-bearing partners via Michael addition, allowing efficient coupling to cysteine residues on engineered ligands or to thiol-functionalized warheads/handles. In PROTAC design, this linker architecture supports modular assembly by separating binding elements with a hydrophilic spacer and by providing a reliable attachment point for downstream synthesis and optimization. It is particularly valuable for generating series of conjugates to probe how linker length and attachment chemistry influence degradation potency and selectivity in cellular assays.
Structure of 477781-69-4
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Benzyl-PEG4-MS is a polyethylene glycol–based PROTAC linker designed to provide a flexible, hydrophilic spacer between a ligand and an E3-recruiting module. Its ether-rich PEG scaffold supports favorable solubility and conformational adaptability, which can improve productive ternary complex formation in targeted protein degradation workflows. The benzyl group and methanesulfonyl (mesyl) functionality enable practical, modular synthesis and coupling strategies. Detailed structural and reactivity considerations for PROTAC construction are provided below.
Structure: The linker comprises a PEG chain with repeating ether units, imparting strong hydrogen-bonding capacity and high polarity. A benzyl substituent provides an aromatic handle, while a mesyl leaving group enables substitution chemistry. Overall, it behaves as a flexible, ether-containing spacer with stable C–O and aromatic C–C frameworks.
Reactivity: The mesyl group is suited for nucleophilic substitution reactions commonly used to connect PROTAC fragments. In typical linker installation or final assembly steps, nucleophiles such as amines or thiols can displace the mesyl moiety under mild base-promoted conditions. Suitable solvents include polar aprotic media, and catalysts are generally unnecessary when using activated nucleophiles. The reaction proceeds via a leaving-group–enabled substitution mechanism, allowing efficient formation of the desired linker–ligand bond.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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