Benzyl-PEG7-NHBoc
Cat No.: BP-501922
Purity: >95%
4.5 
Benzyl-PEG7-NHBoc is a polyethylene glycol (PEG) linker building block featuring a benzyl-protected terminus and a Boc-protected amine at the other end, providing a chemically stable, water-compatible spacer for PROTAC assembly. The PEG segment confers conformational flexibility and improves solubility, while the benzyl group serves as a hydrophobic handle that can assist in positioning the linker within ternary-complex geometries. The Boc-protected amine enables controlled post-coupling functionalization, allowing researchers to install this linker between a target-binding ligand and an E3 ligase ligand through standard amide or related coupling chemistries after deprotection. In targeted protein degradation workflows, such PEG linkers are widely used to tune linker length, reduce steric clashes, and modulate the effective distance and relative orientation required for productive recruitment of the target protein to the ubiquitin–proteasome machinery. This product is therefore valuable for generating rational PROTAC analog panels and optimizing degradation potency and selectivity in vitro.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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Popular Publications Citing BOC Sciences Products
Benzyl-PEG7-NHBoc is a polyethylene glycol-based PROTAC linker building block designed to provide a flexible, hydrophilic spacer between a ligand and an electrophilic or functionalized coupling handle. Its PEG character supports favorable solubility and conformational adaptability, which can improve productive engagement of target proteins and E3 ligases in targeted protein degradation workflows. The sections below describe the linker’s structural features and practical considerations for PROTAC assembly.
Structure: This linker combines a benzyl ether terminus with a PEG chain and a protected amine (Boc). It contains ether linkages along the polyether backbone and a carbamate protecting group, yielding a flexible, polar scaffold suitable for bioconjugation and iterative synthesis.
Reactivity: The Boc-protected amine is typically introduced or retained during coupling steps, then deprotected under standard acid-mediated Boc removal conditions to reveal a free amine for subsequent bond formation. PROTAC construction commonly uses amide or carbamate-forming coupling chemistries with activated carboxylic acid derivatives, employing appropriate bases and polar organic solvents to maintain PEG compatibility and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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