Benzyl-PEG8-acid
Cat No.: BP-501931
Purity: >95%
4.5 
Benzyl-PEG8-acid is a PEG-based PROTAC linker featuring a benzyl terminus and a terminal carboxylic acid, with an approximately eight-unit ethylene glycol chain that provides a flexible, hydrophilic spacer between conjugated modules. The ether-rich PEG backbone enhances aqueous solubility and conformational freedom, helping the two functional partners of a PROTAC—typically a ligand for an E3 ubiquitin ligase and a ligand or binding moiety for the target protein—to approach each other with reduced steric penalty. The benzyl group serves as a stable hydrophobic handle for attachment to the rest of the construct, while the carboxylic acid enables straightforward coupling strategies (e.g., amide formation or other carboxyl-directed conjugations) to connect to amine-bearing ligands or to downstream linkers. In targeted protein degradation research, such PEG linkers are widely used to tune linker length, flexibility, and physicochemical properties, often improving productive ternary complex formation and thereby supporting systematic optimization of PROTAC potency and selectivity.
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* For research and manufacturing use only. Not for human or clinical use.
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Benzyl-PEG8-acid is a polyethylene glycol (PEG)-based PROTAC linker building block designed to provide flexible spacing and improved solubility between a ligand and an E3-recruiting or target-binding moiety. Its acid functionality enables robust conjugation strategies commonly used in targeted protein degradation workflows. The linker’s ether-rich scaffold supports conformational adaptability, which can help maintain productive ternary complex formation. Detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a benzyl-terminated PEG chain bearing a terminal carboxylic acid. Its backbone is dominated by ether linkages, offering rotational flexibility and hydrophilicity, while the aromatic benzyl group provides a stable hydrophobic handle. The terminal acid enables formation of amide or ester derivatives under standard coupling conditions.
Reactivity: The carboxylic acid can be activated for amide-bond formation with amine-bearing ligands via common peptide-coupling chemistries. Typical approaches use coupling reagents and base in polar aprotic solvents, followed by purification to remove residual activators. The ether-rich PEG segment is generally stable under mild coupling conditions and is compatible with PROTAC assembly steps that rely on amide linkage formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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