Bis(NHS)PEG9
CAS No.: 1008402-79-6
Cat No.: BP-500203
Purity: ≥98%
4.5 
Bis(NHS)PEG9 is a bifunctional polyethylene glycol linker bearing two N-hydroxysuccinimide (NHS) ester termini, enabling efficient, chemistry-driven conjugation to primary amines on targeting ligands and protein-binding modules. The PEG spacer provides a flexible, hydrophilic chain that helps reduce steric congestion and can improve productive orientation between the two conjugated partners in a PROTAC architecture. In targeted protein degradation workflows, such PEG-NHS linkers are commonly used to install stable amide connections, allowing researchers to tether an E3 ligase ligand to a second binding moiety (e.g., a warhead or another recognition element) while maintaining sufficient linker length and conformational freedom for ternary complex formation. Its value lies in providing a straightforward route to generate well-defined conjugates for systematic structure–activity studies, facilitating optimization of degradation potency and selectivity by tuning linker geometry and attachment sites.
Structure of 1008402-79-6
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Bis(NHS)PEG9 is a bifunctional PEG-based linker designed for constructing PROTACs through efficient amide-bond formation with primary amine–containing ligands. Its dual N-hydroxysuccinimide (NHS) ester functionality enables controlled, high-yield conjugation under mild conditions, supporting modular assembly of targeted protein degraders. The PEG spacer provides conformational flexibility and improved aqueous compatibility, which can help maintain productive ternary complex formation. Detailed structural and reactivity considerations are provided below.
Structure: The molecule contains a PEG-based repeating ether backbone bearing two NHS ester groups. The NHS esters are activated carboxyl derivatives, enabling nucleophilic acyl substitution. Overall, it is an amphiphilic, water-compatible linker with flexible, ether-rich segments that reduce steric constraints during conjugation.
Reactivity: Suitable PROTAC assembly typically uses NHS ester chemistry with primary amines on targeting ligands or handles. Reactions are commonly performed in anhydrous or low-water organic solvents or mixed aqueous buffers at mildly basic pH to preserve NHS reactivity while promoting amine nucleophilicity. No special catalysts are generally required; the mechanism proceeds via nucleophilic acyl substitution, forming stable amide bonds. Freshly prepared linker solutions and exclusion of competing nucleophiles (e.g., excess amines) are recommended.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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