Biotin-PEG3-alcohol

 CAS No.: 289714-02-9  Cat No.: BP-500893 4.5  

Biotin-PEG3-alcohol is a biotin-functionalized, short-chain polyethylene glycol linker bearing a terminal hydroxyl group, providing a flexible hydrophilic spacer between a biotin affinity handle and an alcohol-reactive end. In PROTAC and targeted degradation workflows, this scaffold is useful for constructing conjugates that require reliable capture or immobilization via streptavidin/avidin binding, while the PEG spacer helps reduce steric interference and can improve effective presentation of the attached moiety. The terminal alcohol enables straightforward incorporation into experimental designs that use alcohol-compatible coupling chemistries (for example, formation of activated derivatives or ether/ester linkages), allowing researchers to position the biotin tag for affinity purification, assay readouts, or surface/solid-phase engagement of degradation constructs. As a modular linker, it supports systematic optimization of linker length and polarity in targeted protein degradation research, facilitating reproducible handling and downstream analytical workflows.

Biotin-PEG3-alcohol

Structure of 289714-02-9

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PROTAC Linker
Molecular Formula
C₁₆H₂₉N₃O₅S
Molecular Weight
375.48

* For research and manufacturing use only. Not for human or clinical use.

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IUPACName
5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide
Synonyms
(+)-Biotin-PEG3-OH
InChI Key
JMPJDHGWKSPEEE-YDHLFZDLSA-N
InChI
InChI=1S/C16H29N3O5S/c20-6-8-24-10-9-23-7-5-17-14(21)4-2-1-3-13-15-12(11-25-13)18-16(22)19-15/h12-13,15,20H,1-11H2,(H,17,21)(H2,18,19,22)/t12-,13-,15-/m0/s1
SMILES
C1C2C(C(S1)CCCCC(=O)NCCOCCOCCO)NC(=O)N2

Biotin-PEG3-alcohol is a PEG-based linker designed to support PROTAC assembly by providing a hydrophilic, flexible spacer between a biotin-derived recognition element and an alcohol-functional handle for subsequent conjugation. Its ether-rich backbone improves solubility and conformational adaptability, which can help tune ternary-complex formation in targeted protein degradation workflows.

Structure: Biotin-PEG3-alcohol features a biotin moiety connected through a short poly(ethylene glycol) chain terminating in a primary alcohol. The linker contains ether linkages within the PEG segment and an alcohol functional group, offering high polarity, hydrogen-bonding capacity, and conformational flexibility typical of PEG spacers.

Reactivity: The terminal alcohol enables common PROTAC linker coupling strategies such as esterification or ether formation using activated carboxylic acids or electrophilic sulfonate/halide derivatives, typically under mild base or acid catalysis depending on the partner. PEG ether linkages are generally stable under standard amide/ester coupling conditions. Solvents such as polar aprotic media and aqueous-compatible buffers are commonly used to maintain solubility and preserve functional group integrity during conjugation.

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It is commonly abbreviated as: C1V1 = C2V2

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Historical Records: S-acetyl-PEG6-Tos | Amino-PEG3-alcohol | PEG3-bis(phosphonic acid diethyl ester) | (2-Pyridyldithio)-PEG4-propargyl | Amino-PEG23-amine | Azido-PEG10-NHS ester | Cbz-N-PEG15-amine | Bromo-PEG1-NH2 hydrobromide | TCO-PEG12-NHS ester | m-PEG9-phosphonic acid | Biotin-PEG3-alcohol

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