Bis-PEG10-t-butyl ester
Cat No.: BP-501948
Purity: ≥95%
4.5 
Bis-PEG10-t-butyl ester is a bifunctional polyethylene glycol (PEG) linker featuring two PEG10 arms capped with tert-butyl ester groups. Structurally, it provides a flexible, hydrophilic spacer that can be engineered to connect two PROTAC-relevant fragments while maintaining favorable solubility and reducing nonproductive hydrophobic interactions. In PROTAC design, such bis-PEG linkers act as molecular “bridges” that position a ligand for an E3 ubiquitin ligase and a ligand for the target protein at an appropriate distance and orientation to promote ternary complex formation and subsequent ubiquitination-driven degradation. The tert-butyl ester termini enable controlled chemical derivatization under standard linker-modification conditions, facilitating conjugation to carboxylate- or amine-bearing warheads or ligands. This product is valuable for researchers seeking modular, water-compatible PROTAC architectures, especially when longer reach and conformational flexibility are required to optimize cooperative binding and degradation potency in vitro.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This PROTAC linker, Bis-PEG10-t-butyl ester, is designed to provide a PEG-based, flexible spacer that can enhance aqueous solubility and support productive geometry between a ligand and an E3-recruiting module. Its bis-ester functionality enables controlled, modular attachment strategies commonly used in targeted protein degradation workflows. The following sections describe the structural features and practical reactivity considerations for constructing PROTACs using this linker in research settings.
Structure: The linker consists of a bis-functional polyethylene glycol scaffold bearing tert-butyl ester groups. It contains ether linkages that confer hydrophilicity and conformational flexibility, while the ester motifs provide chemically addressable handles for downstream conjugation. The overall architecture supports stable, solvated constructs suitable for bioconjugation.
Reactivity: tert-Butyl ester groups are typically cleaved under mild acid to generate carboxylic acids, enabling subsequent coupling to amines or other nucleophiles via standard amide-forming chemistries. PROTAC assembly commonly uses activation reagents (for example, carbodiimide or uronium-type coupling systems) in compatible solvents such as polar aprotic media. Mechanistically, ester hydrolysis precedes nucleophilic acyl substitution, and reaction conditions are chosen to preserve sensitive ligands and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
