Name: CHO-Ph-CONH-PEG3-NHBoc
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO

Appearance

Light Yellow or White Solid

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl N-[2-[2-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]ethoxy]ethyl]carbamate

Synonyms

Ald-Ph-PEG3-NH-Boc; DF-PEG3-NH-Boc; Ald-Ph-amido-C2-PEG3-NH-Boc; tert-butyl (1-(4-formylphenyl)-1-oxo-5,8,11-trioxa-2-azatridecan-13-yl)carbamate; 5,8,11-Trioxa-2,14-diazapentadecanoic acid, 15-(4-formylphenyl)-15-oxo-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl [13-(4-formylphenyl)-13-oxo-3,6,9-trioxa-12-azatridec-1-yl]carbamate; Carbamic acid, N-[13-(4-formylphenyl)-13-oxo-3,6,9-trioxa-12-azatridec-1-yl]-, 1,1-dimethylethyl ester

InChI Key

AHMIDXZZBNCXCP-UHFFFAOYSA-N

InChI

InChI=1S/C21H32N2O7/c1-21(2,3)30-20(26)23-9-11-28-13-15-29-14-12-27-10-8-22-19(25)18-6-4-17(16-24)5-7-18/h4-7,16H,8-15H2,1-3H3,(H,22,25)(H,23,26)

SMILES

CC(C)(C)OC(=O)NCCOCCOCCOCCNC(=O)C1=CC=C(C=C1)C=O

CHO-Ph-CONH-PEG3-NHBoc, is designed to provide a flexible polyethylene glycol (PEG) spacer that supports efficient spatial coupling between a ligand and an E3-recruiting or target-binding module. Its ether-rich backbone can improve solubility and conformational adaptability, which are commonly beneficial for targeted protein degradation workflows. The following sections describe its structural features and practical reactivity considerations for assembling PROTAC architectures.

Structure: The linker contains an aromatic phenyl core connected through a carbonyl and an amide linkage, followed by a PEG3 ethylene glycol chain. A terminal Boc-protected amine enables controlled functional-group transformations. Overall, it presents a polar, hydrogen-bonding capable scaffold with ether-rich flexibility.

Reactivity: The Boc-protected amine is suitable for stepwise PROTAC synthesis, enabling deprotection under standard acid-mediated Boc removal conditions to reveal a reactive primary amine. This amine can then participate in amide bond formation with activated carboxylic acids or acyl derivatives using coupling reagents typical for peptide/bioconjugation chemistry. Solvent systems compatible with PEG-containing linkers are generally preferred to maintain solubility and minimize side reactions.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂