Bis-PEG25-acid
Cat No.: BP-501858
4.5 
Bis-PEG25-acid is a bifunctional polyethylene glycol (PEG) linker bearing two terminal carboxylic acid groups, providing a long, flexible, water-compatible spacer for PROTAC assembly. Structurally, the molecule consists of two PEG chains connected through a central scaffold, with each chain terminating in an acid functionality that can be used for amide or ester coupling to ligands such as E3 ligase recruiters and target-binding warheads. In PROTAC design, this “bis-linker” architecture enables controlled conjugation of two different binding modules while reducing steric clashes and maintaining sufficient conformational freedom for ternary complex formation. The extended PEG length and hydrophilicity can also improve solubility and mitigate nonspecific hydrophobic interactions, which is often beneficial when optimizing linker length and attachment chemistry. As a modular component, Bis-PEG25-acid supports systematic linker engineering in targeted protein degradation studies, facilitating reproducible synthesis and comparative evaluation of degradation potency and selectivity.
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* For research and manufacturing use only. Not for human or clinical use.
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Bis-PEG25-acid is a PEG-based bifunctional linker designed to connect a ligand for an E3 ligase to a target-binding moiety in PROTAC architectures. Its flexible, hydrophilic PEG framework helps tune linker length and conformational freedom, often improving solubility and facilitating productive ternary complex formation. The acid functionality enables robust conjugation strategies, supporting systematic structure–activity studies. The detailed structural and synthetic considerations are provided below.
Structure: Bis-PEG25-acid comprises a polyethylene glycol scaffold bearing carboxylic acid functionality, providing a flexible, water-compatible linker. Ether linkages within the PEG chain impart conformational mobility, while terminal acidic groups enable amide or related bond formation. Overall, the molecule is expected to be highly polar and readily soluble in aqueous media.
Reactivity: The carboxylic acid groups are suitable for coupling reactions commonly used in PROTAC synthesis, including formation of amide bonds with amine-bearing ligands. Typical approaches employ activated carboxylic acid intermediates generated using standard coupling reagents under mild base and controlled temperature, often in polar aprotic solvents or mixed aqueous/organic systems. The reaction proceeds via nucleophilic acyl substitution, and purification is generally guided by the polarity of PEG-containing intermediates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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