Bis-PEG29-acid
Cat No.: BP-501906
4.5 
Bis-PEG29-acid is a bifunctional PEG-based linker featuring two terminal carboxylic acid groups connected through a long polyethylene glycol chain, providing a flexible, hydrophilic spacer suitable for PROTAC assembly. Its extended PEG length and ether-rich backbone help reduce steric hindrance between the two binding modules, while the carboxylates enable robust conjugation strategies (e.g., activation to form amide bonds) to attach an E3-ligase ligand and a target-binding ligand through stable covalent linkages. In targeted protein degradation designs, such flexible linkers can improve the effective concentration and productive geometry required for ternary complex formation, thereby supporting efficient recruitment of the E3 ligase to the target protein. This linker is particularly valuable when optimizing linker length and flexibility to balance solubility, conformational freedom, and degradation potency in structure–activity studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Bis-PEG29-acid is a PEG-based bifunctional linker designed to connect a target-binding ligand to an E3 ligase recruiter in PROTAC architectures. Its flexible, hydrated polyether segment supports productive ternary complex formation while the terminal carboxylic acid enables robust conjugation strategies. This linker’s balanced solubility and conformational adaptability make it useful for constructing degraders where linker length and polarity influence degradation efficiency. The following points describe its structure and practical reactivity considerations in detail below.
Structure: The molecule is a bis-PEG scaffold bearing terminal carboxylic acid functionality. It contains repeating ether units that provide high conformational flexibility and strong hydrogen-bonding/solvation behavior. The linker presents stable carbon–oxygen ether bonds and a carboxylate-bearing reactive end group suitable for amide or ester-forming chemistry.
Reactivity: The carboxylic acid end group is typically activated for coupling to amine- or hydroxyl-functional ligands via standard PROTAC linker synthesis routes. Common approaches include carboxyl activation using carbodiimides with coupling additives, or conversion to an acid-derivative followed by nucleophilic substitution. Reactions are generally performed under anhydrous or low-water conditions in compatible organic solvents with controlled pH to suppress hydrolysis and maintain coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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