Azido-Thalidomide

 CAS No.: 2098488-36-7  Cat No.: BP-100009  Purity: ≥98% 4.5  

Azido-Thalidomide is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand thalidomide conjugated to an alkyl linker with terminal azide group.

Azido-Thalidomide

Structure of 2098488-36-7

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C19H20N6O6
Molecular Weight
428.405

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥98%
ShelfLife
2 years
Storage
-20°C
Synonyms
E3 ligase Ligand-Linker Conjugates 18; N-(4-azidobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
InChI Key
USWFAZSQVLTHHA-UHFFFAOYSA-N
InChI
InChI=1S/C19H20N6O6/c20-24-22-9-2-1-8-21-15(27)10-31-13-5-3-4-11-16(13)19(30)25(18(11)29)12-6-7-14(26)23-17(12)28/h3-5,12H,1-2,6-10H2,(H,21,27)(H,23,26,28)
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCCN=[N+]=[N-]
1. Facile synthesis of an azido-labeled thalidomide analogue
Scott M Capitosti, Todd P Hansen, Milton L Brown Org Lett. 2003 Aug 7;5(16):2865-7. doi: 10.1021/ol034906w.
[reaction: see text] A five-step synthesis of an azido-thalidomide analogue is presented. The sequence requires cheap and readily available starting materials and reagents, and only two steps require purification. Additionally, the azido-labeled analogue possesses activity comparable to that of thalidomide in inhibiting the proliferation of human microvascular endothelial cells, thus providing impetus for its use as a potential photoaffinity label of thalidomide.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: ABBV-744 | Pomalidomide-PEG2-NH2 dihydrochloride | (S,R,S)-AHPC-PEG2-NH2 hydrochloride | cIAP1 Ligand-Linker Conjugates 6 hydrochloride | (S,R,S)-AHPC-PEG1-azide | PROTAC K-Ras Degrader-1 | Pomalidomide-PEG1-azide | VH 032-linker 6 | Pomalidomide-PEG5-CO2H | Gefitinib | Azido-Thalidomide

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