MS-PEG8-THP
Cat No.: BP-502002
4.5 
MS-PEG8-THP is a heterobifunctional polyethylene glycol linker designed for PROTAC and related targeted protein degradation constructs, combining a methanesulfonate (MS) leaving group with an oligo(ethylene glycol) chain of intermediate length terminated by a thioether/THP-type handle. Its PEG backbone provides conformational flexibility and aqueous solubility, helping to reduce steric mismatch between the two PROTAC-binding modules and to tune the effective distance for productive ternary complex formation. The MS functionality enables covalent conjugation to nucleophilic sites on one partner molecule (commonly via substitution reactions), while the remaining THP-derived termination supports orthogonal attachment to the second component. In experimental workflows, this linker is valuable for systematically varying linker length and attachment chemistry to optimize degradation potency and selectivity, improve pharmacokinetic-like handling in vitro, and facilitate modular synthesis of degraders for mechanistic studies of ubiquitin–ligase recruitment and substrate engagement.
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* For research and manufacturing use only. Not for human or clinical use.
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MS-PEG8-THP is a polyethylene glycol (PEG)-based PROTAC linker designed to connect a target-binding ligand to an E3 ligase recruiting element while providing conformational flexibility and improved aqueous compatibility. Its ether-rich PEG scaffold helps tune linker length, reduce steric constraints, and support efficient formation of productive ternary complexes in targeted protein degradation workflows. The detailed structural and synthetic considerations are provided below.
Structure: The linker comprises a PEG chain featuring repeating ether units that impart hydrophilicity and conformational flexibility. It is terminated with a functional group suitable for conjugation to PROTAC building blocks, enabling stable covalent attachment through standard linker–ligand coupling chemistries.
Reactivity: MS-PEG8-THP is intended for PROTAC assembly via covalent coupling to complementary reactive handles on ligands. Typical strategies include nucleophilic substitution or amide/ether-forming reactions, selected according to the terminal functional group of the linker and the partner ligand. Mild base or coupling reagents, compatible solvents such as polar aprotic media, and controlled reaction temperatures are commonly used to preserve sensitive pharmacophores and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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