Boc-HyNic-PEG2-N3
Cat No.: BP-501809
4.5 
Boc-HyNic-PEG2-N3 is a bifunctional PROTAC linker featuring a Boc-protected hydrazinonicotinamide (HyNic) motif conjugated to a short, flexible polyethylene glycol (PEG) spacer terminating in an azide (N3). The PEG2 segment provides conformational flexibility and improved aqueous compatibility, while the HyNic hydrazide functionality enables chemoselective coupling to aldehyde-bearing partners through hydrazone formation, a widely used strategy in targeted conjugation workflows. The azide handle allows orthogonal attachment via azide–alkyne cycloaddition (CuAAC or strain-promoted variants) to install or connect the complementary recognition or E3-ligase–binding module without interfering with the HyNic chemistry. In PROTAC design, this dual-reactive architecture supports modular assembly, enabling researchers to tune linker length and geometry to optimize ternary complex formation and degradation efficiency. The product is therefore valuable for constructing well-defined, conjugation-ready PROTAC intermediates for systematic structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Boc-HyNic-PEG2-N3 is a polyethylene glycol-based PROTAC linker building block designed to support efficient conjugation between targeting ligands and E3 ligase recruiters. Its PEG spacer provides conformational flexibility and improved solubility, while the HyNic-derived hydrazide functionality enables chemoselective coupling strategies commonly used in targeted protein degradation workflows. The azide handle further facilitates orthogonal reactions for modular assembly. Detailed structural and reactivity considerations are provided below.
Structure: The molecule contains a PEG spacer segment, an N3 azide group for bioorthogonal functionalization, and a Boc-protected HyNic-derived hydrazide motif. It features carbamate and amide linkages, along with ether linkages characteristic of PEG. The overall structure supports aqueous compatibility and flexible linker behavior.
Reactivity: For PROTAC construction, the azide functionality is typically used in click-type conjugations with complementary alkynes under copper-free or copper-catalyzed conditions, depending on compatibility with other components. The HyNic hydrazide group is commonly engaged in hydrazone formation with aldehyde-bearing partners, often driven by mild acid catalysis and controlled pH. Boc protection can be removed under standard deprotection conditions to enable subsequent coupling steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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