Boc-NH-PEG12-propargyl
Cat No.: BP-501746
4.5 
Boc-NH-PEG12-propargyl is a Boc-protected amino-terminated polyethylene glycol linker bearing a terminal propargyl (alkyne) handle, providing a flexible, water-soluble chain of extended length suitable for bioconjugation chemistry. Structurally, the PEG segment acts as a hydrophilic spacer that can reduce steric interference and improve the effective reach between a ligand-binding warhead and a recruited E3 ligase moiety in PROTAC constructs. The propargyl group enables chemoselective attachment via copper-catalyzed azide–alkyne cycloaddition (“click”) or related alkyne-reactive coupling strategies, while the Boc-protected amine supports controlled deprotection and subsequent amide/urea formation during linker assembly. In targeted protein degradation research, such PEG linkers are widely used to tune linker length, conformational freedom, and solubility, thereby facilitating systematic optimization of degradation potency, cooperativity, and cellular uptake. This product is therefore valuable for constructing modular PROTACs and related targeted degraders where reliable, orthogonal conjugation is required.
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* For research and manufacturing use only. Not for human or clinical use.
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Boc-NH-PEG12-propargyl is a PEG-based PROTAC linker building block designed to connect targeting ligands to E3 ligase recruiters through a stable, flexible hydrophilic spacer and a terminal alkyne handle. Its Boc-protected amine enables controlled conjugation workflows, while the propargyl group supports efficient “click” coupling strategies commonly used in targeted protein degradation. The following sections describe its structure and practical reactivity considerations in PROTAC assembly.
Structure: The molecule comprises a Boc-protected amine attached to a polyethylene glycol chain terminating in a propargyl (alkyne) functionality. It contains carbamate and ether linkages within a flexible, polar PEG scaffold, providing water-compatible solubility and conformational adaptability for linker-mediated ternary complex formation.
Reactivity: The propargyl terminus is suited for copper(I)-catalyzed azide–alkyne cycloaddition to form stable triazole linkages with azide-functional partners under standard click conditions. The Boc group can be removed using acid to reveal the free amine for amide or urea-forming coupling, enabling stepwise PROTAC synthesis. Typical workflows employ inert atmospheres, compatible polar solvents, and copper sources with appropriate ligands to manage alkyne reactivity and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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