Boc-NH-PEG20-CH2CH2COOH
Cat No.: BP-501811
4.5 
Boc-NH-PEG20-CH2CH2COOH is a polyethylene glycol (PEG)-based bifunctional linker featuring a Boc-protected amine at one terminus and a terminal carboxylic acid separated by a short ethylene spacer at the other. The PEG segment provides a flexible, hydrophilic chain that can reduce steric constraints and improve solubility when conjugated to protein-binding ligands and E3-ligase recruiters. In PROTAC architectures, this linker functions as a spacer that positions the two binding moieties at an appropriate distance and relative orientation to promote ternary complex formation and efficient ubiquitination-driven degradation. The terminal Boc group enables controlled amide or carbamate coupling after deprotection, while the carboxylic acid supports standard coupling chemistries (e.g., EDC/NHS-mediated activation) to attach to complementary functional groups. This product is valuable for systematic linker optimization in targeted protein degradation research, where tuning length, flexibility, and attachment chemistry can strongly influence degradation potency and selectivity.
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker, Boc-NH-PEG20-CH2CH2COOH, is designed to provide a flexible, hydrophilic spacer between a ligand and a reactive handle for conjugation in targeted protein degradation workflows. Its PEG-based architecture can improve solubility and reduce steric constraints during ternary complex formation, supporting efficient recruitment of the target protein. The following sections describe the structure and the practical reactivity considerations for assembling PROTAC constructs.
Structure: The linker contains a Boc-protected amine, a polyethylene glycol segment, and a terminal carboxylic acid. It features ether linkages within the PEG chain, along with amide/urethane-compatible functional groups and a flexible aliphatic spacer, enabling favorable aqueous solubility and conformational mobility.
Reactivity: The terminal carboxylic acid is suitable for amide-bond formation via standard coupling chemistries (e.g., carbodiimide-mediated activation with an amine-containing partner). The Boc group can be removed under acidic conditions to reveal the free amine when needed for subsequent coupling steps. Typical procedures use polar aprotic solvents and base/activator systems to promote efficient conjugation while minimizing side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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