Boc-NH-PEG24-CH2CH2COOH
Cat No.: BP-501814
4.5 
Boc-NH-PEG24-CH2CH2COOH is a Boc-protected amino-terminated polyethylene glycol linker bearing a terminal carboxylic acid, providing a long, flexible hydrophilic spacer between a PROTAC warhead and an E3 ligase-binding ligand. The PEG chain length and ether-rich backbone confer conformational mobility and water solubility, while the Boc group enables controlled amide-bond formation after deprotection. The terminal carboxyl group serves as a robust handle for coupling to amines on target-binding or ligase-binding components, typically via standard peptide coupling chemistries, yielding stable amide linkages that preserve the functional orientation of both binding moieties. In targeted protein degradation research, such PEG linkers can reduce steric interference, improve effective molarity at the ternary complex interface, and help tune physicochemical properties that influence cellular uptake and proteasome-dependent degradation efficiency. This linker is therefore valuable for systematic PROTAC optimization and for constructing conjugates requiring extended reach and minimized nonspecific interactions.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This PEG-based PROTAC linker, Boc-protected and terminated with a carboxylic acid, is designed to provide a flexible, water-compatible spacer between a target-binding ligand and an E3 ligase recruiting moiety. Its ether-rich backbone supports favorable solubility and conformational adaptability, which can improve productive ternary complex formation in targeted protein degradation workflows. The detailed Structure and Reactivity parameters are provided below.
Structure: The molecule comprises a Boc-protected amine connected to an extended poly(ethylene glycol) chain bearing a terminal ethyl spacer and a carboxylic acid. It contains ether linkages along the PEG segment, an amide (from the Boc-protected nitrogen), and a terminal carboxyl group suitable for coupling chemistry.
Reactivity: The carboxylic acid enables standard PROTAC linker functionalization via amide-bond formation or ester activation, typically using peptide-coupling reagents under mild base conditions. The Boc group can be removed using acid to reveal the primary amine for subsequent conjugation. Solvent systems commonly include polar aprotic media for coupling; reaction design should preserve PEG integrity and minimize hydrolysis during activation and coupling steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
