Boc-NH-PEG36-CH2CH2COOH
Cat No.: BP-501983
4.5 
Boc-NH-PEG36-CH2CH2COOH is a Boc-protected amino-terminated polyethylene glycol (PEG) linker bearing a terminal carboxylic acid, providing a long, flexible hydrophilic chain that separates two functional moieties. Structurally, it contains an N-protected amine for controlled coupling chemistry, an extended PEG segment that enhances aqueous solubility and reduces nonspecific hydrophobic interactions, and a distal carboxyl group suitable for amide-bond formation or other conjugation strategies. In PROTAC design, this type of linker acts as a molecular “spacer” that tunes the effective distance and relative orientation between the ligand for an E3 ubiquitin ligase and the target-binding warhead, thereby improving productive ternary complex formation and degradation efficiency. Its PEG-rich architecture also helps mitigate aggregation and can improve handling in biological media, making it valuable for systematic linker-length and geometry optimization in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This PEG-based PROTAC linker, Boc-protected at the terminal amine and terminated with a carboxylic acid, is designed to provide a hydrophilic, conformationally flexible spacer between a ligand and a warhead. Its ether-rich backbone can improve solubility and reduce steric constraints, which are common challenges in targeted protein degradation workflows. The following points describe its structure and practical reactivity for PROTAC assembly in detail below.
Structure: The linker contains a Boc-protected amino group connected to a long poly(ethylene glycol) chain featuring repeating ether linkages, ending in a flexible ethylene spacer and a terminal carboxylic acid. It includes amide-relevant functionality (protected amine) and a carboxyl group capable of forming stable derivatives.
Reactivity: The terminal carboxylic acid enables coupling to complementary amines or activated intermediates commonly used in PROTAC synthesis, including amide bond formation via carbodiimide/active ester strategies. The Boc group is typically removed under standard acid-mediated deprotection conditions to unmask the amine for subsequent conjugation. Reaction planning should consider PEG compatibility, aqueous/organic solvent choice, and maintaining mild conditions to preserve linker integrity during assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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