Bromoacetamido-PEG9-ethylcarbamoyl-C4-Boc
Cat No.: BP-501864
4.5 
Bromoacetamido-PEG9-ethylcarbamoyl-C4-Boc is a heterobifunctional, PEG-based PROTAC linker featuring a bromoacetamide electrophile at one terminus and a tert-butyl ester-protected carboxyl functionality at the other, separated by a long, flexible PEG9 segment. The bromoacetamide group is designed to form a stable covalent bond with nucleophilic residues (commonly cysteine thiols) on a ligand-bearing warhead, enabling site-specific attachment of the linker to targeted protein-binding modules. The extended PEG chain provides conformational flexibility and improved solubility, helping maintain productive geometry between the recruited ligand and the E3 ligase-binding partner. In PROTAC construction, this linker supports controlled conjugation chemistry and can be used to tune linker length and polarity to optimize ternary complex formation and degradation potency. It is therefore valuable for systematic linker optimization and for experiments requiring robust, covalent tethering strategies in targeted protein degradation workflows.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This Bromoacetamido-PEG9-ethylcarbamoyl-C4-Boc linker is engineered for efficient conjugation in PROTAC architectures, providing a PEG-based spacer that can tune linker length, polarity, and conformational flexibility while preserving bioorthogonal reactivity. Its bromoacetamide functionality enables targeted nucleophilic substitution to install protein-binding warheads or handle subsequent assembly steps. The Boc-protected group supports controlled functional group transformations during synthesis. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains an ether-rich PEG segment that confers hydrophilicity and conformational flexibility, connected to a bromoacetamide electrophile and an ethylcarbamoyl motif. A Boc-protected functionality provides acid-labile protection, while the bromoacetamide features a polarized carbon–bromine bond suitable for substitution.
Reactivity: The bromoacetamide group reacts with nucleophiles such as primary amines and thiols via an SN2-type substitution, forming stable C–N or C–S linkages. PROTAC assembly is typically performed under anhydrous or low-water conditions using polar aprotic solvents, with base selection tailored to maintain nucleophile reactivity while minimizing side reactions. Boc deprotection is commonly achieved under mild acid conditions when required for subsequent coupling steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
