Bromoacetyl-PEG3-DBCO
Cat No.: BP-502027
Purity: >95%
4.5 
Bromoacetyl-PEG3-DBCO is a heterobifunctional PEG-based linker featuring a bromoacetyl electrophile and a cyclooctyne (DBCO) strained-alkyne handle connected through a short three-unit polyethylene glycol spacer. The bromoacetyl group readily undergoes nucleophilic substitution with thiols or other suitable nucleophiles, enabling stable conjugation to cysteine-containing ligands, peptides, or other targeting modules. The DBCO moiety then participates in copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azide-functional partners, allowing orthogonal “click” assembly without additional metal catalysts. In PROTAC and targeted protein degradation workflows, this combination supports modular construction of degraders by first installing the PEG spacer onto one component via the bromoacetyl chemistry and subsequently coupling the second component through SPAAC, preserving linker flexibility and improving conjugation efficiency. This product is valuable for researchers seeking reliable, sequential conjugation strategies to generate well-defined PROTAC architectures for mechanistic studies and optimization experiments.
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* For research and manufacturing use only. Not for human or clinical use.
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Bromoacetyl-PEG3-DBCO is a bifunctional PEG-based linker designed for modular PROTAC assembly, combining a reactive bromoacetyl electrophile with a strained-alkyne DBCO handle for efficient conjugation. Its polyethylene glycol segment supports favorable solubility and linker flexibility, which can improve productive ternary complex formation. This molecule will be described in detail below, including its structural features and practical reactivity considerations for constructing PROTACs.
Structure: The linker contains a bromoacetyl group attached to a short polyethylene glycol chain terminating in a DBCO moiety. It features an alkyl bromide electrophile, ether linkages within the PEG segment, and a cyclooctyne-based strained alkyne suitable for copper-free cycloaddition. Overall, it is an amphiphilic, conjugation-ready scaffold.
Reactivity: The bromoacetyl functionality undergoes nucleophilic substitution/alkylation with appropriate nucleophiles (for example, amines or thiols) under standard organic synthesis conditions. The DBCO group participates in strain-promoted azide–alkyne cycloaddition with azide-bearing partners without copper catalysis, typically in compatible solvents that maintain solubility. For PROTAC construction, sequential conjugation strategies are commonly used to preserve functional group integrity and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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