Name: CHO-Ph-CONH-PEG2-COOtBu
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]propanoate

Synonyms

Ald-Ph-PEG2-t-butyl ester; DF-PEG2-CH2CH2COOtBu; Ald-Ph-amido-PEG2-C2-Boc; Ald-Ph-PEG2-COOtBu; Ald-Ph-PEG2-CH2CH2COOtBu; tert-butyl 3-(2-(2-(4-formylbenzamido)ethoxy)ethoxy)propanoate; Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl 3-(2-{2-[(4-formylbenzoyl)amino]ethoxy}ethoxy)propanoate

Boiling Point

547.6±45.0°C (Predicted)

Density

1.132±0.06 g/cm3 (Predicted)

InChI Key

UXMPBIQFYCJYBB-UHFFFAOYSA-N

InChI

InChI=1S/C19H27NO6/c1-19(2,3)26-17(22)8-10-24-12-13-25-11-9-20-18(23)16-6-4-15(14-21)5-7-16/h4-7,14H,8-13H2,1-3H3,(H,20,23)

SMILES

CC(C)(C)OC(=O)CCOCCOCCNC(=O)C1=CC=C(C=C1)C=O

CHO-Ph-CONH-PEG2-COOtBu, is designed to connect a binding ligand to an E3-recruiting moiety through a flexible polyethylene glycol spacer and a stable amide linkage. Its ether-rich PEG segment can improve solubility and conformational adaptability, supporting efficient formation of productive ternary complexes. The protected carboxylate functionality enables modular conjugation strategies used in targeted protein degradation workflows.

Structure: The linker contains an aromatic phenyl ring linked to a carbonyl and an amide nitrogen, followed by a short polyethylene glycol segment and a terminal ester-protected carboxylate. It features amide and ether linkages, with a tert-butyl ester that is chemically stable under mild conditions yet readily deprotected when needed.

Reactivity: The tert-butyl ester can be deprotected using standard acid-mediated conditions to reveal a carboxylic acid for subsequent coupling. For PROTAC assembly, carboxylate activation (for example, via common coupling reagents) enables formation of amide bonds with complementary amine-bearing ligands. The PEG-containing portion is generally compatible with aqueous/organic solvent mixtures used in peptide-ligand conjugation, supporting reliable stepwise synthesis.

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂