Thiol-PEG6-acid
CAS No.: 1347750-77-9
Cat No.: BP-501720
Purity: >95%
4.5 
Thiol-PEG6-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal thiol for site-specific conjugation and a carboxylic acid handle for controlled coupling or further functionalization. Structurally, it provides a flexible, hydrophilic PEG chain of intermediate length that can spatially separate a targeting ligand or protein-binding moiety from an E3 ligase recruiter, helping to reduce steric hindrance and improve productive ternary-complex formation in PROTAC constructs. In targeted protein degradation design, the thiol enables robust attachment to electrophilic partners (or to thiol-reactive handles on other building blocks), while the carboxyl group supports amide or ester formation under standard coupling chemistries. Its PEG-based, water-soluble architecture is widely used to tune solubility, maintain conformational freedom, and facilitate modular synthesis of conjugates. This linker is therefore valuable for researchers optimizing PROTAC linker length, attachment chemistry, and overall degradation efficiency in vitro.
Structure of 1347750-77-9
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Thiols and PEG-based spacers are widely used in PROTAC linker design to tune solubility, conformational flexibility, and the effective distance between ligand-binding motifs. Thiol-PEG6-acid provides a functional handle for chemoselective conjugation and a hydrophilic, biocompatible polymer segment that can improve productive ternary complex formation. The points below describe the structure and practical reactivity considerations for building PROTACs using this linker.
Structure: Thiol-PEG6-acid is a PEG-linked carboxylic acid bearing a terminal thiol. The linker comprises repeating ether units that confer hydrophilicity and flexibility, along with a thiofunctional group for coupling. The carboxylic acid enables salt formation and controlled reactivity in subsequent steps.
Reactivity: The terminal thiol supports thiol–maleimide or thiol–activated ester conjugation strategies under mild conditions, typically using aqueous or mixed aqueous/organic solvents and pH regimes compatible with thiol stability. The carboxylic acid can be activated for amide bond formation via common coupling chemistries. Careful control of oxidation-sensitive thiol handling, including inert atmosphere and fresh solutions, is often required.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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