cIAP1 Ligand-Linker Conjugates 5

Background Introduction

cIAP1 Ligand-Linker Conjugates 5 are specialized bifunctional molecules designed for use in targeted protein degradation technologies such as PROTACs (Proteolysis Targeting Chimeras). These conjugates feature a ligand that specifically binds to cellular inhibitor of apoptosis protein 1 (cIAP1), an E3 ubiquitin ligase, connected via a chemically optimized linker to facilitate efficient PROTAC synthesis.

Mechanism

The mechanism of cIAP1 Ligand-Linker Conjugates 5 centers on their ability to recruit the cIAP1 E3 ligase to a target protein of interest. In PROTAC applications, these conjugates are linked to a ligand for the target protein, forming a heterobifunctional molecule. When introduced into cells, the PROTAC simultaneously binds the target protein and cIAP1. This proximity enables cIAP1 to ubiquitinate the target protein, marking it for rapid recognition and degradation by the proteasome. The efficiency and selectivity of cIAP1 recruitment are enhanced by the carefully engineered ligand and flexible linker in this compound.

Applications

cIAP1 Ligand-Linker Conjugates 5 are valuable building blocks for researchers developing PROTAC molecules focused on targeted protein degradation. Their primary applications include: 1) serving as E3 ligase recruiting elements in the generation of novel PROTACs, 2) facilitating the study of cIAP1-mediated ubiquitination pathways, and 3) enabling high-throughput screening of protein targets for degradation in drug discovery and therapeutic research. This product is essential for academic and industrial labs aiming to create selective degraders for hard-to-drug proteins using the cIAP1 E3 ligase system.

• Facilitates efficient recruitment of cIAP1 E3 ligase for targeted protein degradation applications.
• Pre-optimized linker design streamlines PROTAC synthesis, saving valuable research and development time.