Biotin-PEG6-Boc
CAS No.: 1352814-07-3
Cat No.: BP-501496
4.5 
Biotin-PEG6-Boc is a heterobifunctional PEG-based linker featuring a biotin handle for high-affinity streptavidin capture and a Boc-protected functional group that can be deprotected to enable subsequent coupling reactions. Structurally, it comprises a flexible, hydrophilic polyethylene glycol chain of six ethylene glycol units that spaces the biotin from the reactive terminus, improving solubility and reducing steric interference during conjugation. In PROTAC and targeted protein degradation workflows, such linkers are valuable as modular “attachment arms” for assembling multifunctional constructs, for example by immobilizing or purifying PROTAC intermediates via streptavidin affinity or by providing a controlled attachment point for conjugation to other ligands, handles, or carrier moieties. The PEG spacer and biotin–streptavidin interaction together facilitate robust experimental workflows, including affinity capture, surface immobilization, and purification of degradation reagents, thereby supporting reproducible synthesis and characterization of targeted degradation systems.
Structure of 1352814-07-3
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Biotin-PEG6-Boc is a PEG-based, biotin-functionalized PROTAC linker designed to support modular assembly of targeted protein degraders. Its polyethylene glycol scaffold provides conformational flexibility and aqueous compatibility, while the tert-butyl ester-protected carboxyl functionality enables controlled coupling strategies during PROTAC synthesis. The biotin handle can facilitate orthogonal attachment or enrichment workflows commonly used in PROTAC research. Detailed structural and synthetic considerations are provided below.
Structure: The linker combines a biotin moiety with a flexible polyethylene glycol chain and a tert-butyl ester-protected carboxyl group. It contains ether linkages within the PEG segment, amide connectivity to the biotin moiety, ester functionality at the tert-butyl-protected carboxyl group, and multiple heteroatoms that support hydrogen bonding and enhanced solubility in polar media.
Reactivity: The tert-butyl ester can be cleaved under mild acid conditions to generate the corresponding carboxylic acid for subsequent bond formation. PROTAC assembly can employ activation of the resulting carboxylic acid followed by amide coupling to amine-containing partners using standard coupling reagents in compatible organic solvents. The PEG ether backbone is generally stable under these conditions, supporting reliable linker integrity during synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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