DBCO-NHCO-PEG12-amine
Cat No.: BP-501728
4.5 
DBCO-NHCO-PEG12-amine is a heterobifunctional polyethylene glycol (PEG) linker bearing a DBCO (dibenzocyclooctyne) cyclooctyne for strain-promoted azide–alkyne cycloaddition (SPAAC) and a terminal primary amine for subsequent conjugation chemistry. Structurally, it comprises a DBCO moiety connected through a carbamate (NHCO) to a long, flexible PEG chain, terminating in an amine that can be used to couple to activated carboxylates, isothiocyanates, or other electrophiles. In PROTAC and targeted degradation workflows, this linker is valuable as a modular “click-ready” spacer that positions two functional partners with minimal steric interference while enabling efficient, catalyst-free attachment to azide-functionalized ligands or payloads. The PEG segment improves solubility and reduces nonspecific interactions, often enhancing the practical assembly and handling of multicomponent degraders. Researchers use DBCO–PEG–amine linkers to streamline synthesis of conjugates and to tune linker length and flexibility for optimizing degradation efficiency and cellular performance.
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* For research and manufacturing use only. Not for human or clinical use.
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This DBCO-NHCO-PEG12-amine linker is designed for efficient conjugation in targeted protein degradation workflows, enabling the modular assembly of PROTACs through robust bioorthogonal chemistry. Its DBCO handle supports highly selective cycloaddition with azide-functional partners, while the PEG spacer and terminal amine provide solubility, conformational flexibility, and practical functional-group compatibility. The points below describe its structure and the key reactivity considerations for PROTAC construction in research settings.
Structure: The molecule combines a DBCO moiety with an amide-containing spacer connected to a PEG chain terminating in a primary amine. It contains heteroatoms from the PEG ether units and amide linkages, offering hydrogen-bonding capability. The overall architecture provides a flexible, hydrophilic spacer suited for bioconjugation.
Reactivity: The DBCO group undergoes strain-promoted azide–alkyne cycloaddition with azide-bearing ligands under catalyst-free, mild conditions typical of bioorthogonal conjugation. The terminal amine enables further coupling to activated carboxylates or other electrophiles using standard amide-forming chemistries. Reactions are commonly performed in aqueous or mixed aqueous buffers compatible with protein-ligand conjugation, with careful control of pH to preserve linker and partner stability.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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