DNP-PEG2-COOH
CAS No.: 1353011-89-8
Cat No.: BP-501555
Purity: ≥95%
4.5 
DNP-PEG2-COOH is a heterobifunctional polyethylene glycol linker bearing a dinitrophenyl (DNP) recognition handle and a terminal carboxylic acid for subsequent conjugation. Structurally, it comprises a short PEG chain that provides aqueous solubility and conformational flexibility while maintaining a defined attachment point for coupling chemistry. In PROTAC and related targeted degradation designs, the DNP motif can be used to engage DNP-binding protein tags (e.g., anti-DNP binders) to position a recruiting module near the target-binding or E3-ligase–binding component. The terminal carboxyl group enables amide bond formation or other carboxyl-reactive coupling strategies, allowing researchers to connect the linker to ligands, scaffolds, or spacer regions with controlled geometry. This product is valuable for building modular, water-compatible degradation constructs, facilitating optimization of linker length and attachment chemistry to improve effective proximity and degradation potency in cellular assays.
Structure of 1353011-89-8
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DNP-PEG2-COOH is a polyethylene glycol-based PROTAC linker bearing a DNP-derived recognition handle and a terminal carboxylic acid for controlled conjugation. Its flexible PEG segment supports productive spatial presentation of binding motifs and can improve solubility and linker-mediated conformational freedom in targeted protein degradation constructs. The following sections describe its structural features and practical guidance for assembling PROTACs using this linker.
Structure: The linker consists of a short PEG ether chain terminated by a carboxylic acid, providing a flexible, hydrophilic segment. It contains ether linkages along the PEG backbone and a terminal carboxyl group capable of forming stable amide or ester derivatives under standard coupling conditions.
Reactivity: The carboxylic acid is suitable for PROTAC assembly via amide bond formation with amine-bearing warheads or ligands using carbodiimide-based coupling systems, often with additives that suppress side reactions. Typical conditions employ polar aprotic solvents and controlled pH to promote efficient activation and nucleophilic acyl substitution. The PEG ether portion is generally stable to these coupling chemistries, enabling straightforward conjugation without disrupting the linker scaffold.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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