Pomalidomide-C2-NH2

Background Introduction

Pomalidomide-C2-NH2 is a functionalized derivative of pomalidomide, one of the potent immunomodulatory imide drugs (IMiDs) widely used as a cereblon (CRBN) E3 ligase ligand in targeted protein degradation research. The inclusion of a C2 (two-carbon) amino linker at the imide moiety endows this molecule with increased chemical reactivity and synthetic flexibility, facilitating its use as a building block for PROTAC (Proteolysis Targeting Chimera) and other heterobifunctional degrader constructs. Such modifications are vital for tuning the physicochemical properties and biological compatibility of degrader molecules.

Mechanism

Pomalidomide-C2-NH2 functions by specifically binding to the cereblon (CRBN) component of the CRL4-CRBN E3 ubiquitin ligase complex. In the context of PROTAC chemistry, the exposed C2-amino linker provides an accessible conjugation point for attaching a variety of target protein ligands via amide bond formation or other coupling reactions. Once successfully tethered to a target-ligand motif, the resulting PROTAC molecule can simultaneously engage both CRBN and the protein of interest, thereby facilitating the recruitment of the ubiquitin-proteasome system to polyubiquitinate and degrade the target protein within cells.

Applications

Pomalidomide-C2-NH2 is ideal for drug discovery scientists and medicinal chemists focusing on the design and synthesis of CRBN-based PROTACs, molecular glues, and other heterobifunctional degraders. Its primary applications include:

• Serving as an E3 ligase binding moiety in the construction of CRBN-recruiting PROTACs
• Customized synthesis of molecular glues aimed at novel protein targets
• Structure-activity relationship (SAR) and linker optimization studies for targeted protein degraders
• Facilitating biological and mechanistic studies in both academic and pharmaceutical research settings

By providing a chemically versatile handle, Pomalidomide-C2-NH2 accelerates innovation in targeted protein degradation and supports the rapid prototyping of next-generation degrader therapeutics.

• High-purity compound verified by HPLC, NMR, and LC-MS
• Consistent batch-to-batch reproducibility with complete QC documentation
• Supplied with COA, MSDS, and analytical data for traceability
• Reliable global shipping with stability-guaranteed packaging
• Dedicated technical support and optional custom synthesis service
• Demonstrates strong binding affinity to CRBN, VHL, or other E3 ligases
• Enables stable E3 ligase recruitment for targeted protein degradation
• Amino-functionalized linker enables straightforward attachment of diverse warheads for PROTAC development.
• Optimized for high-affinity binding to CRBN, ensuring efficient targeted protein degradation.