Pomalidomide-C2-NH2

 CAS No.: 1957235-66-3  Cat No.: BP-200002  Purity: > 98% 4.5  

Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

Pomalidomide-C2-NH2

Structure of 1957235-66-3

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Category
Ligand for E3 Ligase
Molecular Formula
C15H16N4O4
Molecular Weight
316.31
Appearance
White to Yellow Powder

* For research and manufacturing use only. Not for human or clinical use.

SizePriceStockQuantity
25 mg $199 In stock
100 mg $523 In stock

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Purity
> 98%
Solubility
10 mM in DMSO
Appearance
White to Yellow Powder
Storage
2 - 8 °C, protect from light.
Shipping
Room temperature in continental US; may vary elsewhere
IUPACName
4-(2-aminoethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Synonyms
4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; SCHEMBL17884390; TQP0427; Cereblon Ligand-Linker Conjugates 15; HY-128846; Pomalidomide-C2-NH2; Pomalidomide-alkylC2-amine; E3 ligase Ligand 17; 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Boiling Point
633.6±55.0 °C (Predicted)
Density
1.496±0.06 g/cm3 (Predicted)
InChI Key
WYIGFEKILOYHCT-UHFFFAOYSA-N
InChI
InChI=1S/C15H16N4O4/c16-6-7-17-9-3-1-2-8-12(9)15(23)19(14(8)22)10-4-5-11(20)18-13(10)21/h1-3,10,17H,4-7,16H2,(H,18,20,21)
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCN

Can you tell me the special storage conditions of Pomalidomide-C2-NH2?

Yes, I can. Keep in dark place, Inert atmosphere, Room temperature.

6/2/2016

Can you give me some information about the structure of Pomalidomide-C2-NH2

Pomalidomide-C2-NH2 is a synthetic E3 ligand linker conjugate containing Pomalidomide-based cereblon ligand and a linker.

2/4/2019

E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand

We used Pomalidomide-C2-NH2 as a synthesized E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a linker in my experiment, it worked well.

3/3/2019

Stock concentration: *
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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

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